Stephens C J, McFadden J P, Black M M, Rycroft R J
St. John's Institute of Dermatology, St. Thomas' Hospital, UK.
Contact Dermatitis. 1994 Aug;31(2):108-10. doi: 10.1111/j.1600-0536.1994.tb01928.x.
Autoimmune progesterone dermatitis is a rare condition, characterized by recurrent premenstrual exacerbations of a dermatosis, in which sensitivity to progesterone can be demonstrated. The sensitizing mechanism is unknown. The aim of this study was to test the hypothesis that cross-sensitivity between steroid groups could induce allergy to endogenous progesterone in these patients. 5 patients with autoimmune progesterone dermatitis and 1 with oestrogen-sensitive dermatitis have been patch tested with a corticosteroid series, conjugated oestrogen 1% in petrolatum (pet.), and 17-alpha-OH-progesterone 2% pet. There were no immediate or delayed reactions at 2 and 4 days to any steroid group. We have therefore been unable to demonstrate steroid cross-sensitivity, or a use for 17-alpha-OH-progesterone in the investigation of oestrogen - and progesterone-sensitive dermatoses.
自身免疫性孕酮性皮炎是一种罕见病症，其特征为皮肤病在月经前反复加重，且可证实对孕酮敏感。致敏机制尚不清楚。本研究的目的是检验这样一个假设，即类固醇组之间的交叉敏感性可能会在这些患者中诱发对内源性孕酮的过敏反应。对5例自身免疫性孕酮性皮炎患者和1例对雌激素敏感的皮炎患者进行了皮质类固醇系列、凡士林（pet.）中1%结合雌激素以及凡士林（pet.）中2% 17-α-羟基孕酮的斑贴试验。在第2天和第4天，对任何类固醇组均未出现即刻或延迟反应。因此，我们无法证实类固醇交叉敏感性，也无法证明17-α-羟基孕酮在雌激素和孕酮敏感性皮肤病的研究中的用途。
