EAA Central Facility, Faculty of Life Sciences, University of Manchester, Manchester, UK.
J Clin Pathol. 2011 Oct;64(10):930-2. doi: 10.1136/jclinpath-2011-200068. Epub 2011 Apr 22.
The prothrombin time/international normalised ratio (PT/INR) Line method to derive INR, based on only five European Concerted Action on Anticoagulation (ECAA) certified plasmas, is shown to be reliable in previous ECAA studies. A simpler method not requiring linear regression calculation would be an advantage.
After determining the local PT/INR Line, local INRs have been obtained using a readily available spreadsheet on the internet which laboratories can use without performing any additional calculations.
Examples of INR derivation have been obtained from results at 16 centres using a range of local coagulometers with human thromboplastin international reference preparations (IRPs). The procedure does not require manual PT testing, local international sensitivity index calibration, availability of thromboplastin IRPs or local mean normal prothrombin time.
From the PT/INR Line, INR values for local PT results are easily obtained using an Excel spreadsheet from our website (http://www.anticoagulants.co.uk/) which does not require the complex linear regression analysis to derive INR.
基于仅五个欧洲抗凝协同行动（ECAA）认证的血浆，推导 INR 的凝血酶原时间/国际标准化比值（PT/INR）直线法在之前的 ECAA 研究中被证明是可靠的。不需要线性回归计算的更简单方法将是一个优势。
确定本地 PT/INR 直线后，可使用互联网上现成的电子表格获得本地 INR，实验室无需进行任何额外计算即可使用。
使用一系列带有人类组织凝血活酶国际参考制剂（IRP）的本地凝血仪，从 16 个中心的结果中获得了 INR 推导的示例。该程序不需要手动 PT 检测、本地国际敏感指数校准、组织凝血活酶 IRP 的可用性或本地平均正常凝血酶原时间。
从 PT/INR 直线，使用我们网站（http://www.anticoagulants.co.uk/）上的 Excel 电子表格可以轻松获得本地 PT 结果的 INR 值，该电子表格不需要进行复杂的线性回归分析来推导 INR。
