Gjedde A, de la Monte S M, Caronna J J
Acta Physiol Scand. 1977 Jul;100(3):273-81. doi: 10.1111/j.1748-1716.1977.tb05950.x.
The cerebral blood flow and, in some rats, the cerebral rate of oxygen consumption were measured in three groups of male rats. Fractionation of radioisotope-labeled microspheres was used to measure regional cerebral blood flow in four parts of the rat brain. The arterial and cerebral venous concentrations of radioactive xenon during desaturation were used to measure the blood flow and oxygen consumption of cortex when venous blood was collected from the superior sagittal sinus, or of whole brain when the transverse sinus was sampled. The regional cerebral flow measured with microspheres had a large standard error reflecting the technical difficulty of this method. The cerebral blood flow measured with xenon was higher when venous blood was sampled from the superior sagittal sinus than when sampled from the transverse sinus, but cerebral oxygen consumption rates were similar. The difference reflects the greater trauma involved in the superior sagittal approach and possible extracerebral contamination present in the transverse sinus approach.
对三组雄性大鼠测量了脑血流量，部分大鼠还测量了脑氧耗率。采用放射性同位素标记微球的分级分离法来测量大鼠脑四个部位的局部脑血流量。当从上矢状窦采集静脉血时，利用氙气脱饱和过程中动脉血和脑静脉血中的放射性氙浓度来测量皮质的血流量和氧耗量；当从横窦采样时，则测量全脑的血流量和氧耗量。用微球测量的局部脑血流量有较大的标准误差，这反映了该方法的技术难度。从上矢状窦采集静脉血时用氙气测量的脑血流量高于从横窦采样时，但脑氧耗率相似。这种差异反映了上矢状窦采血法涉及的创伤更大，以及横窦采血法可能存在的脑外污染。
