Parwaresch M R, Haacke H, Mäder C
Atherosclerosis. 1978 Dec;31(4):395-401. doi: 10.1016/0021-9150(78)90134-x.
The hypolipidemic and antiatherogenic effects of different nicotinic acid derivatives were studied. Five rabbit groups maintained on an atherogenic diet were given simultaneously various nicotinic acid derivatives (50 mg/kg body weight/day): nicotinic acid, Xantinol-nicotinate, beta-pyridylcarbinol or Pirozadil (bis-3,4,5-trimethoxybenzoate, 2,6-pyridindiyldimethylene). All 4 compounds showed a clear hypocholesterolemic and antiatherogenic effect, as measured by serum cholesterol, and by planimetric evaluation of the aortic lesions in terms of percent surface area affected in the aortas and coronary lumen. The simultaneously observed elevation of the HDL/LDL cholesterol ratio of the aortic tissue possibly indicates an antiatherogenic effect of these changes.
研究了不同烟酸衍生物的降血脂和抗动脉粥样硬化作用。给五组维持致动脉粥样硬化饮食的兔子同时给予各种烟酸衍生物（50毫克/千克体重/天）：烟酸、烟酸占替诺、β-吡啶甲醇或吡罗扎地（双-3,4,5-三甲氧基苯甲酸，2,6-吡啶二亚甲基）。通过血清胆固醇以及对主动脉病变进行平面测量评估主动脉和冠状动脉管腔受影响的表面积百分比，所有这4种化合物均显示出明显的降胆固醇和抗动脉粥样硬化作用。同时观察到的主动脉组织中高密度脂蛋白/低密度脂蛋白胆固醇比值升高可能表明这些变化具有抗动脉粥样硬化作用。
