幽门螺杆菌感染降低食管鳞状细胞癌风险：伊朗的一项病例对照研究
Helicobacter pylori infection reduces the risk of esophageal squamous cell carcinoma: a case-control study in iran.
作者信息
Khoshbaten Manouchehr, Zadimani Ali, Bonyadi Mohammad Reza, Mohammadzadeh Mohammad, Gachkar Latif, Pourhoseingholi Mohamad Amin
机构信息
Infectious Disease Research Center, Iran.
出版信息
Asian Pac J Cancer Prev. 2011;12(1):149-51.
BACKGROUND
Some studies have indicated a protective role of H.pylori against risk of esophageal squamous cell carcinoma (ESCC). The purpose of this study was to explore this possible relationship in a case-control study.
METHODS
One hundred consecutive patients diagnosed with ESCC and 100 healthy people were entered with informed consent. All were asked to provide a blood sample and serum immunoglobulin G (IgG) antibodies against HP-CSAs were measured with an enzyme-linked immunosorbent assay (ELISA).
RESULTS
There was significant reverse association between H. pylori positivity and tumour development (OR=0.28, 95% CI: 0.15-0.54), but not with a Cag A positive status.
CONCLUSION
Our findings provide further evidence that H. pylori infection decreases the risk of ESCC but that this is not linked to a Cag A positive status.
背景
一些研究表明幽门螺杆菌对食管鳞状细胞癌（ESCC）风险具有保护作用。本研究的目的是在一项病例对照研究中探讨这种可能的关系。
方法
100例连续诊断为ESCC的患者和100名健康人在获得知情同意后纳入研究。所有受试者均被要求提供血样，并采用酶联免疫吸附测定（ELISA）检测血清抗幽门螺杆菌细胞毒素相关蛋白A（HP-CSAs）免疫球蛋白G（IgG）抗体。
结果
幽门螺杆菌阳性与肿瘤发生之间存在显著的负相关（OR=0.28，95%可信区间：0.15-0.54），但与细胞毒素相关基因A（Cag A）阳性状态无关。
结论
我们的研究结果进一步证明，幽门螺杆菌感染可降低ESCC风险，但这与Cag A阳性状态无关。
Zotero 插件