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未成熟胸腺细胞的阴性和阳性选择:时机及αβ T细胞受体配体的作用

Negative and positive selection of immature thymocytes: timing and the role of the ligand for alpha beta T cell receptor.

作者信息

Kisielow P, von Boehmer H

机构信息

Basel Institute for Immunology, Switzerland.

出版信息

Semin Immunol. 1990 Jan;2(1):35-44.

PMID:2151796
Abstract

Recent experiments show that CD4+8+ thymocytes represent the critical stage in T cell development at which the specificity of randomly generated ab T cell receptors is screened. These cells are deleted when the receptor binds to the MHC molecule plus specific peptide presented by bone marrow derived cells but are rescued from cell death and induced to mature if the receptor binds to the MHC molecule on thymic epithelium in the absence of the specific peptide. Different tolerogens delete CD4+8+ thymocytes earlier or later during their lifespan and negative selection can occur prior to positive selection. The specificity of the ab T cell receptor for either class I or class II thymic MHC molecules determines the CD4-8+ and CD4+8- phenotype of mature T cells.

摘要

最近的实验表明,CD4+8+胸腺细胞代表了T细胞发育的关键阶段,在此阶段随机产生的αβT细胞受体的特异性会受到筛选。当受体与骨髓来源细胞呈递的MHC分子加特异性肽结合时,这些细胞会被清除,但如果受体在没有特异性肽的情况下与胸腺上皮细胞上的MHC分子结合,则这些细胞会从细胞死亡中被拯救出来并被诱导成熟。不同的致耐受原在CD4+8+胸腺细胞的生命周期中或早或晚地使其清除,并且阴性选择可先于阳性选择发生。αβT细胞受体对I类或II类胸腺MHC分子的特异性决定了成熟T细胞的CD4-8+和CD4+8-表型。

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