在胸腺对T细胞库进行选择的过程中，CD4和CD8作为共受体发挥作用。
CD4 and CD8 act as co-receptors during thymic selection of the T cell repertoire.
作者信息
Zúñiga-Pflücker J C, Jones L A, Chin L T, Kruisbeek A M
机构信息
Biological Response Modifiers Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
出版信息
Semin Immunol. 1991 May;3(3):167-75.
PMID:1909594
Abstract
The selection of T cell receptor specificities must logically not only involve the alpha beta-TCR but, also the CD4 and CD8 molecules, as antigen recognition by the alpha beta-TCR on mature T cells is facilitated by the CD4 and CD8 co-receptors. In this review, the studies that provided key advances in our understanding of the possible role of CD4 and CD8 in T cell development will be discussed.
摘要
T细胞受体特异性的选择在逻辑上必然不仅涉及αβ-TCR，还涉及CD4和CD8分子，因为成熟T细胞上的αβ-TCR对抗原的识别是由CD4和CD8共受体促进的。在这篇综述中，将讨论那些在我们对CD4和CD8在T细胞发育中可能作用的理解方面取得关键进展的研究。
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