Institute of Neuropathology, University of Bonn Medical Center, Bonn, Germany.
Neuropathology. 2011 Dec;31(6):654-7. doi: 10.1111/j.1440-1789.2011.01220.x. Epub 2011 Apr 26.
Rosette-forming glioneuronal tumors (RGNT) of the fourth ventricle are rare mixed glio-neuronal tumors included in the revised WHO classification of CNS tumors and show histopathological features similar to pilocytic astrocytomas. To evaluate at molecular level potential affinities between these tumors, we investigated a case of RGNT, arising in the cerebellum of a young patient, for the presence of transcriptional products originating from the KIAA1549-BRAF fusion. However, the analysis did not show any fusion. Further studies in larger RGNT case series are needed in order to demonstrate the possible presence of KIAA1549-BRAF fusion and better delineate its relationship with pilocytic astrocytomas.
第四脑室的菊形团形成性神经胶质神经元肿瘤（RGNT）是一种罕见的混合性神经胶质神经元肿瘤，包含在 CNS 肿瘤的 WHO 修订分类中，具有类似于毛细胞星形细胞瘤的组织病理学特征。为了在分子水平上评估这些肿瘤之间的潜在亲和力，我们研究了一例发生在小脑的 RGNT 病例，以检测 KIAA1549-BRAF 融合的转录产物的存在。然而，分析并未显示任何融合。需要对更大的 RGNT 病例系列进行进一步研究，以证明 KIAA1549-BRAF 融合的可能存在，并更好地阐明其与毛细胞星形细胞瘤的关系。
