D'Cruz F, Samsudin A T, Hamid M S, Abraham T
Department of Paediatrics, Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan.
Med J Malaysia. 1990 Jun;45(2):123-30.
A prospective study of acute nephritis in children was conducted at the Universiti Sains Malaysia Hospital, Kubang Kerian between July 1987 and June 1988. One hundred and twenty four children were admitted with acute glomerulonephritis. The aim of the study was to determine the clinical pattern of the nephritis as well as its aetiology. The majority of our patients came from the lower socio-economic group and 54% of the families had incomes below the poverty line. Preceding skin infection was much more common than throat infection. The children showed a high incidence of complications: severe hypertension (43.6%), hypertensive encephalopathy (11.3%), clinical pulmonary oedema (36.3%), severe azotaemia (10.5%), and prolonged gross haematuria (13.7%). By using immunologic indices such as ASOT, anti-DNase B and complement 3, it was concluded that 121 of the 124 patients had post-streptococcal nephritis.
1987年7月至1988年6月期间，在马来西亚理科大学古邦哥里安医院对儿童急性肾炎进行了一项前瞻性研究。124名儿童因急性肾小球肾炎入院。该研究的目的是确定肾炎的临床模式及其病因。我们的大多数患者来自社会经济地位较低的群体，54%的家庭收入低于贫困线。皮肤感染先于咽喉感染更为常见。这些儿童并发症的发生率很高：严重高血压（43.6%）、高血压脑病（11.3%）、临床肺水肿（36.3%）、严重氮质血症（10.5%）和持续性肉眼血尿（13.7%）。通过使用诸如抗链球菌溶血素O、抗脱氧核糖核酸酶B和补体3等免疫学指标，得出结论：124例患者中有121例患有链球菌感染后肾炎。
