Department of Chemistry, Mahila MahaVidyalaya, Banaras Hindu University, Varanasi-221005, UP, India.
Curr Med Chem. 2011;18(14):2174-85. doi: 10.2174/092986711795656234.
Lymphatic filariasis, onchocerciasis and loiasis caused by human filarial nematodes are diseases of tropical and subtropical countries causing considerable morbidity. The available control strategies have significant limitations such that current drugs are ineffective against macrofilariae (adult worms), require repeated and prolonged treatment over years and are threatened by emergence of drug resistance. Due to this concern, these diseases are the focus of renewed scientific interest and much has been done in filariasis research in the past decade. This review summarizes the current status of filariasis, different control strategies, recent advances in antifilarial chemotherapy including currently used drugs, their pros and cons, their mechanism of action, and recently discovered targets and prototypes.
淋巴丝虫病、盘尾丝虫病和由人体丝虫引起的罗阿丝虫病是热带和亚热带国家的疾病，可导致相当高的发病率。现有的控制策略存在显著的局限性，例如，现有药物对微丝蚴（成虫）无效，需要多年来重复和长期治疗，并且存在耐药性出现的威胁。由于这一担忧，这些疾病成为重新引起科学界关注的焦点，过去十年中在丝虫病研究方面做了很多工作。本综述总结了丝虫病的现状、不同的控制策略、抗丝虫化学疗法的最新进展，包括目前使用的药物、它们的优缺点、作用机制，以及最近发现的靶标和原型。
