Behm Carolyn A, Bendig Mary M, McCarter James P, Sluder Ann E
School of Biochemistry and Molecular Biology, Faculty of Science, Australian National University, Canberra 0200, Australia.
Trends Parasitol. 2005 Mar;21(3):97-100. doi: 10.1016/j.pt.2004.12.003.
Human filarial nematodes cause river blindness and lymphatic filariasis, both of which are diseases that produce considerable morbidity. Control of these diseases relies on drug treatments that are ineffective against macrofilariae and are threatened by the development of resistance. New validated drug targets are required to allow development of new classes of antifilarial drugs. To identify and validate potential new drug targets, we propose a collaborative research strategy utilizing bioinformatic filters and assessment of gene function by RNA interference in Caenorhabditis elegans and Brugia malayi.
人类丝虫线虫会导致河盲症和淋巴丝虫病，这两种疾病都会引发相当高的发病率。这些疾病的控制依赖于对成虫无效且面临耐药性发展威胁的药物治疗。需要新的经过验证的药物靶点来开发新型抗丝虫药物。为了识别和验证潜在的新药物靶点，我们提出一种合作研究策略，利用生物信息学筛选以及通过秀丽隐杆线虫和马来布鲁线虫中的RNA干扰来评估基因功能。
