Hamanaka Junya, Hara Hideaki
Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan.
Cent Nerv Syst Agents Med Chem. 2011 Jun 1;11(2):107-13. doi: 10.2174/187152411796011312.
Cerebral ischemia is characterized by obvious inflammatory cell aggregations, up-regulation of cytokine expression, and increased expression of intercellular adhesion molecules. Like systemic bacterial infections, cerebral injury is also associated with innate immunity, a specific immunologic response that utilizes Toll-like receptors (TLRs). The involvement of TLRs in cerebral ischemia is now being confirmed using animal models. Recent reports reveal that mice that lack TLR2 and TLR4 show improved stroke outcomes and that TLR2 and 4 may contribute to neuronal injury that occurs after cerebral ischemia. In this review, we have summarized these recent reports concerning the association of TLRs with cerebral ischemia.
脑缺血的特征是明显的炎症细胞聚集、细胞因子表达上调以及细胞间黏附分子表达增加。与全身性细菌感染一样，脑损伤也与天然免疫有关，天然免疫是一种利用Toll样受体（TLR）的特异性免疫反应。目前正在使用动物模型证实TLR在脑缺血中的作用。最近的报告显示，缺乏TLR2和TLR4的小鼠中风预后有所改善，并且TLR2和4可能导致脑缺血后发生的神经元损伤。在这篇综述中，我们总结了这些关于TLR与脑缺血关联的最新报告。
