Institutes for Advanced Interdisciplinary Research, East China Normal University, Shanghai, China.
Eur J Clin Invest. 2011 Nov;41(11):1245-53. doi: 10.1111/j.1365-2362.2011.02535.x. Epub 2011 Apr 27.
Recent studies have shown that microRNAs (miRNA) could play a potential role as diagnostic and prognostic biomarkers of cancers. The aim of this meta-analysis is to summarize the global predicting role of miR-21 for survival in patients with a variety of carcinomas.
Eligible studies were identified and assessed for quality through multiple search strategies. Data were collected from studies comparing overall, relapse-free or cancer-specific survival (CSS) in patients with cancer having higher miR-21 expression with those having lower levels. Pooled hazard ratios (HRs) of miR-21 for survival were calculated.
A total of 17 studies dealing with various carcinomas were included for this global meta-analysis. For overall survival (OS), the pooled hazard ratio (HR) of higher miR-21 expression in cancerous tissue was 1·69 (95% CI: 1·33-2·16, P < 0·001), which could significantly predict poorer survival in general carcinomas. For relapse-free or CSS, elevated miR-21 was also a significant predictor, with a pooled HR of 1·48 (95% CI: 1·03-2·11, P = 0·033). Importantly, subgroup analysis suggested that higher expression of miR-21 correlated with worse OS in head and neck squamous cell carcinoma (HNSCC) (HR 1·46, 95% CI: 1·13-1·87, P = 0·004) and carcinomas in digestion system (HR 1·56, 95% CI: 1·08-2·26, P = 0·018).
Our findings suggest that miR-21 detection has a prognostic value in patients with cancer, especially in HNSCC and digestion system cancers.
最近的研究表明，microRNAs（miRNA）可能在癌症的诊断和预后生物标志物中发挥潜在作用。本荟萃分析的目的是总结 miR-21 对各种癌症患者生存的总体预测作用。
通过多种搜索策略确定并评估合格的研究，以评估其质量。从比较癌症患者组织中 miR-21 高表达与低表达患者的总生存期（OS）、无复发生存率（RFS）或癌症特异性生存率（CSS）的研究中收集数据。计算 miR-21 对生存的汇总风险比（HR）。
共有 17 项涉及各种癌症的研究被纳入本全球荟萃分析。对于 OS，癌症组织中 miR-21 高表达的汇总 HR 为 1.69（95%CI：1.33-2.16，P<0.001），这可以显著预测总体癌症的生存状况较差。对于 RFS 或 CSS，升高的 miR-21 也是一个显著的预测因素，汇总 HR 为 1.48（95%CI：1.03-2.11，P=0.033）。重要的是，亚组分析表明，miR-21 高表达与头颈部鳞状细胞癌（HNSCC）（HR 1.46，95%CI：1.13-1.87，P=0.004）和消化系统癌症（HR 1.56，95%CI：1.08-2.26，P=0.018）的 OS 较差相关。
我们的研究结果表明，miR-21 检测对癌症患者具有预后价值，尤其是在 HNSCC 和消化系统癌症中。
