Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Clin Endocrinol (Oxf). 2011 Oct;75(4):561-6. doi: 10.1111/j.1365-2265.2011.04075.x.
Prolactin (PRL) is involved in immune regulation and may contribute to an atherogenic phenotype. Previous results on the association of PRL with inflammatory biomarkers have been conflicting and limited by small patient studies. Therefore, we used data from a large population-based sample to assess the cross-sectional associations between serum PRL concentration and high-sensitivity C-reactive protein (hsCRP), fibrinogen, interleukin-6 (IL-6), and white blood cell (WBC) count.
From the population-based Study of Health in Pomerania (SHIP), a total of 3744 subjects were available for the present analyses.
PRL and inflammatory biomarkers were measured. Linear and logistic regression models adjusted for age, sex, body-mass-index, total cholesterol and glucose were analysed.
Multivariable linear regression models revealed a positive association of PRL with WBC. Multivariable logistic regression analyses showed a significant association of PRL with increased IL-6 in non-smokers [highest vs lowest quintile: odds ratio 1·69 (95% confidence interval 1·10-2·58), P = 0·02] and smokers [OR 2·06 (95%-CI 1·10-3·89), P = 0·02]. Similar results were found for WBC in non-smokers [highest vs lowest quintile: OR 2·09 (95%-CI 1·21-3·61), P = 0·01)] but not in smokers. Linear and logistic regression analyses revealed no significant associations of PRL with hsCRP or fibrinogen.
Serum PRL concentrations are associated with inflammatory biomarkers including IL-6 and WBC, but not hsCRP or fibrinogen. The suggested role of PRL in inflammation needs further investigation in future prospective studies.
催乳素（PRL）参与免疫调节，可能有助于形成动脉粥样硬化表型。先前关于 PRL 与炎症生物标志物关联的研究结果存在冲突，且受到小样本患者研究的限制。因此，我们使用来自大型基于人群的样本的数据来评估血清 PRL 浓度与高敏 C 反应蛋白（hsCRP）、纤维蛋白原、白细胞介素-6（IL-6）和白细胞计数之间的横断面关联。
本研究基于基于人群的波罗的海健康研究（SHIP），共有 3744 名受试者可用于本分析。
测量 PRL 和炎症生物标志物。分析了经过年龄、性别、体重指数、总胆固醇和葡萄糖调整的多元线性回归模型和多元逻辑回归模型。
多元线性回归模型显示 PRL 与白细胞计数呈正相关。多元逻辑回归分析显示，PRL 与非吸烟者的 IL-6 升高显著相关[最高五分位与最低五分位相比：比值比 1.69（95%置信区间 1.10-2.58），P = 0.02]和吸烟者[比值比 2.06（95%置信区间 1.10-3.89），P = 0.02]。非吸烟者中白细胞计数也存在类似结果[最高五分位与最低五分位相比：比值比 2.09（95%置信区间 1.21-3.61），P = 0.01)]，但在吸烟者中则不然。线性和逻辑回归分析显示 PRL 与 hsCRP 或纤维蛋白原之间无显著关联。
血清 PRL 浓度与包括 IL-6 和白细胞计数在内的炎症生物标志物相关，但与 hsCRP 或纤维蛋白原无关。PRL 在炎症中的作用需要在未来的前瞻性研究中进一步研究。
