Physiology Department, School of Dentistry, Córdoba National University, Córdoba, Argentina.
J Oral Pathol Med. 2011 Oct;40(9):721-5. doi: 10.1111/j.1600-0714.2011.01042.x. Epub 2011 Apr 26.
Sjögren's syndrome (SS) occurs associated with parotid neoplasm, non-Hodgkin's B-cell lymphoma, which could impair the condition or be life-threatening for patients. The aim of this work was to analyze cell proliferation and apoptosis modifications in acinar, ductal and inflammatory infiltrate in salivary glands (SG) in patients with Sjögren Syndrome, keratoconjunctivitis, or stomatitis sicca or in healthy subjects, to establish parameters that indicate the likelihood of malignancy of the disease in populations at risk.
A study was performed with n = 58 histological samples of lower lip SG from patients diagnosed with SS, keratoconjunctivitis, or stomatitis sicca (SICCA) and from healthy subjects (C). Ki67 and caspase-3 immunolabeling were performed.
The most important result was significant differences between the three study groups in Ki67 and caspase-3 markers (P < 0.0001) in infiltrated lymphocytes.
The results of this work are indicative of a high degree of proliferation (85%) in infiltrated lymphocytes (IL) associated with SS which, according the literature, could be considered a risk. Furthermore, the markers used in this work are widely known and represent a lower cost than others and can be used to determine risk groups within the population of SS patients, enabling their follow-up.
干燥综合征（SS）常并发腮腺肿瘤、非霍奇金 B 细胞淋巴瘤，这些疾病可能使病情恶化或危及患者生命。本研究旨在分析伴有口干、眼干和角结膜炎的 SS 患者、涎腺（SG）腺泡、导管和炎症浸润细胞的细胞增殖和凋亡改变，为高危人群建立提示疾病恶性转化可能性的参数。
对诊断为 SS、口干、眼干和角结膜炎（SICCA）的患者（n=58）和健康对照者（C）的下唇 SG 组织进行了研究。进行 Ki67 和 caspase-3 免疫标记。
三组研究组之间的 Ki67 和 caspase-3 标志物（浸润淋巴细胞，P<0.0001）存在显著差异。
本研究结果表明，与 SS 相关的浸润淋巴细胞（IL）增殖程度高（85%），这与文献报道的风险因素一致。此外，本研究中使用的标志物是广为人知的，成本低于其他标志物，可用于确定 SS 患者人群中的风险组，便于对其进行随访。
