Gomes Pedro de Sousa, Juodzbalys Gintaras, Fernandes Maria Helena, Guobis Zygimantas
Laboratory of Pharmacology and Cellular Biocompatibility, Faculty of Dental Medicine, University of Porto Porto Portugal.
Department of Maxillofacial Surgery, Medical Academy, Lithuanian University of Health Sciences Kaunas Lithuania.
J Oral Maxillofac Res. 2012 Apr 1;3(1):e2. doi: 10.5037/jomr.2012.3102.
The purpose of present paper is to review and critically address the recent advances on the aetiopathogenesis of the Sjögren's syndrome, taking into account the attained clinical features, with particular relevance given to the oral involvement.
A comprehensive review of the available literature between 1970 and 2012, regarding to the aetiopathogenesis and clinical findings related to Sjögren's syndrome was conducted. Eligible studies were identified by searching the electronic literature PubMed, Medline, Embase, and ScienceDirect databases for relevant reports (last search update January 2012), combining the MESH heading term "Sjögren's syndrome", with the words "salivary glands, xerostomia, xerophtalmia, aetiology". The authors checked the references of the selected articles to identify additional eligible publications and contacted the authors, if necessary.
This article addresses a large number of the recent advances in the aetiopathogenesis of the disease, taking into account the attained clinical features of both local and systemic nature. Detailed mechanisms of the hypothesized influence of viral infections, genetic and hormonal factors, and the relevance of the altered glandular homeostasis are critically discussed with particular relevance given to the local and systemic involvement of Sjögren's syndrome.
The increasing number of data published recently on the aetiophatogenesis of Sjögren's syndrome strengthens the hypothesis that this condition, as all autoimmune diseases, is a multifactor disorder. Genetic predisposition, hormonal and environmental factors are thought to be implicated.
本文旨在回顾并批判性地探讨干燥综合征发病机制的最新进展，同时考虑到已有的临床特征，尤其关注口腔受累情况。
对1970年至2012年间关于干燥综合征发病机制及临床发现的现有文献进行全面综述。通过在电子文献PubMed、Medline、Embase和ScienceDirect数据库中搜索相关报告（最后一次搜索更新于2012年1月）来确定符合条件的研究，将医学主题词“干燥综合征”与“唾液腺、口干、眼干、病因”等词相结合。作者检查了所选文章的参考文献以识别其他符合条件的出版物，并在必要时联系了作者。
本文探讨了该疾病发病机制方面的大量最新进展，同时考虑到局部和全身性质的现有临床特征。对病毒感染、遗传和激素因素的假定影响的详细机制以及腺体内稳态改变的相关性进行了批判性讨论，尤其关注干燥综合征的局部和全身受累情况。
最近发表的关于干燥综合征发病机制的数据越来越多，这强化了这样一种假设，即与所有自身免疫性疾病一样，这种疾病是一种多因素疾病。遗传易感性、激素和环境因素被认为与之相关。
