Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan, Republic of China.
Clin Microbiol Infect. 2011 May;17(5):780-4. doi: 10.1111/j.1469-0691.2010.03393.x. Epub 2010 Dec 3.
Meningitis is associated with an imbalance between matrix metalloproteinases (MMPs) and endogenous tissue inhibitors of MMP (TIMPs). Serum and CSF were collected prospectively from all patients with meningitis between January 2008 and December 2008 to measure the concentrations of MMP/TIMP in those patients who underwent a lumbar puncture for a presumptive diagnosis of meningitis. A total of 199 patients were enrolled into the study. The concentrations of CSF MMP-9 and TIMP-1 were significantly higher in the meningitis group compared with the control group (p 0.032 and p <0.001, respectively). However, the CSF TIMP-4 levels were significantly lower in the meningitis groups compared with the control groups (p <0.001). Patients with bacterial meningitis had higher CSF MMP-9 and TIMP-1 levels than those who had aseptic meningitis and controls. Patients with various infectious meningitis etiologies tended to have higher CSF MMP-9 expression by gelatin zymography when compared with the controls. In conclusion, MMP/TIMP system dysregulation was found in patients with meningitis, and CSF MMP and TIMP might act as novel indicators in patients with meningitis.
脑膜炎与基质金属蛋白酶（MMPs）和内源性基质金属蛋白酶抑制剂（TIMPs）之间的失衡有关。2008 年 1 月至 2008 年 12 月期间，前瞻性收集所有脑膜炎患者的血清和脑脊液，以测量那些因疑似脑膜炎而行腰椎穿刺的患者的 MMP/TIMP 浓度。共有 199 名患者纳入研究。与对照组相比，脑膜炎组的脑脊液 MMP-9 和 TIMP-1 浓度明显更高（p<0.032 和 p<0.001）。然而，脑膜炎组的脑脊液 TIMP-4 水平明显低于对照组（p<0.001）。细菌性脑膜炎患者的脑脊液 MMP-9 和 TIMP-1 水平高于无菌性脑膜炎患者和对照组。与对照组相比，各种感染性脑膜炎病因的患者在明胶酶谱法中表现出更高的 CSF MMP-9 表达。总之，脑膜炎患者存在 MMP/TIMP 系统失调，脑脊液 MMP 和 TIMP 可能作为脑膜炎患者的新型指标。
