Hospital Universitario A Coruña, La Coruña.
Am J Transplant. 2011 May;11(5):1035-40. doi: 10.1111/j.1600-6143.2011.03515.x.
In this study we analyzed Spanish Post-Heart-Transplant Tumour Registry data for adult heart transplantation (HT) patients since 1984. Median post-HT follow-up of 4357 patients was 6.7 years. Lung cancer (mainly squamous cell or adenocarcinoma) was diagnosed in 102 (14.0% of patients developing cancers) a mean 6.4 years post-HT. Incidence increased with age at HT from 149 per 100 000 person-years among under-45s to 542 among over-64s; was 4.6 times greater among men than women; and was four times greater among pre-HT smokers (2169 patients) than nonsmokers (2188). The incidence rates in age-at-diagnosis groups with more than one case were significantly greater than GLOBOCAN 2002 estimates for the general Spanish population, and comparison with published data on smoking and lung cancer in the general population suggests that this increase was not due to a greater prevalence of smokers or former smokers among HT patients. Curative surgery, performed in 21 of the 28 operable cases, increased Kaplan-Meier 2-year survival to 70% versus 16% among inoperable patients.
在这项研究中，我们分析了自 1984 年以来西班牙心脏移植后肿瘤登记处的数据，该数据针对的是成年心脏移植（HT）患者。4357 名患者的中位 HT 后随访时间为 6.7 年。102 名（癌症患者的 14.0%）患者被诊断出患有肺癌（主要为鳞状细胞癌或腺癌），平均在 HT 后 6.4 年。发病率随 HT 时的年龄增加而增加，45 岁以下人群每 100000 人年有 149 例，64 岁以上人群每 100000 人年有 542 例；男性比女性高 4.6 倍；与非吸烟者（2188 例）相比，HT 前吸烟者（2169 例）的发病率高 4 倍。在有超过 1 例的年龄组中，诊断组的发病率明显高于全球癌症发病率统计 2002 年西班牙一般人群的估计值，与一般人群吸烟和肺癌的发表数据进行比较表明，这种增加不是由于 HT 患者中吸烟者或前吸烟者的比例更高。在 28 例可手术病例中，有 21 例患者接受了根治性手术，与不可手术患者的 16%相比，Kaplan-Meier 2 年生存率提高至 70%。
