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心脏移植后血液系统癌症发病率的下降。

The falling incidence of hematologic cancer after heart transplantation.

作者信息

Crespo-Leiro M G, Delgado-Jiménez J, López L, Alonso-Pulpón L, González-Vilchez F, Almenar-Bonet L, Rábago G, Pérez-Villa F, Paniagua Martín M J, Arizón Del Prado J M, Sousa-Casasnovas I, Manito-Lorite N, Díaz-Molina B, Pascual-Figal D, Lage-Galle E, Blasco-Peiró T, De la Fuente-Galán L, Muñiz J

机构信息

Hospital Universitario A Coruña, La Coruña, Spain.

出版信息

Clin Transplant. 2014 Oct;28(10):1142-7. doi: 10.1111/ctr.12432. Epub 2014 Oct 1.

DOI:10.1111/ctr.12432
PMID:25100534
Abstract

BACKGROUND

A number of changes in the management of heart transplantation (HT) patients have each tended to reduce the risk of post-HT hematologic cancer, but little information is available concerning the overall effect on incidence in the HT population.

METHODS

Comparison of data from the Spanish Post-Heart-Transplantation Tumour Registry for the periods 1991-2000 and 2001-2010.

RESULTS

The incidence among patients who underwent HT in the latter period was about half that observed in the former, with a particularly marked improvement in regard to incidence more than five yr post-HT.

CONCLUSIONS

Changes in HT patient management have jointly reduced the risk of hematologic cancer in the Spanish HT population. Long-term risk appears to have benefited more than short-term risk.

摘要

背景

心脏移植(HT)患者管理方面的多项改变各自倾向于降低HT后血液系统癌症的风险,但关于对HT人群发病率的总体影响,可用信息很少。

方法

比较西班牙心脏移植后肿瘤登记处1991 - 2000年和2001 - 2010年期间的数据。

结果

后一时期接受HT的患者发病率约为前一时期观察到的一半,在HT后超过5年的发病率方面有特别显著的改善。

结论

HT患者管理方面的改变共同降低了西班牙HT人群中血液系统癌症的风险。长期风险似乎比短期风险受益更多。

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The falling incidence of hematologic cancer after heart transplantation.心脏移植后血液系统癌症发病率的下降。
Clin Transplant. 2014 Oct;28(10):1142-7. doi: 10.1111/ctr.12432. Epub 2014 Oct 1.
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[Spanish Heart Transplantation Registry. 19th Official Report of the Spanish Society of Cardiology Working Group on Heart Failure, Heart Transplantation and Associated Therapies (1984-2007)].[西班牙心脏移植登记处。西班牙心脏病学会心力衰竭、心脏移植及相关治疗工作组第19份官方报告(1984 - 2007年)]
Rev Esp Cardiol. 2008 Nov;61(11):1178-90.
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[Spanish Heart Transplantation Registry. 18th official report of the Spanish Society of Cardiology Working Group on Heart Failure, Heart Transplantation and Associated Therapies (1984-2006)].[西班牙心脏移植登记处。西班牙心脏病学会心力衰竭、心脏移植及相关治疗工作组第18份官方报告(1984 - 2006年)]
Rev Esp Cardiol. 2007 Nov;60(11):1177-87.
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Lung cancer after heart transplantation: results from a large multicenter registry.心脏移植后肺癌:来自大型多中心注册研究的结果。
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Impact of short-term mechanical circulatory support with extracorporeal devices on postoperative outcomes after emergency heart transplantation: data from a multi-institutional Spanish cohort.体外装置短期机械循环支持对急诊心脏移植术后结局的影响:来自西班牙多机构队列的数据
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Morbidity, functional status, and immunosuppressive therapy after heart transplantation: an analysis of the joint International Society for Heart and Lung Transplantation/United Network for Organ Sharing Thoracic Registry.心脏移植后的发病率、功能状态及免疫抑制治疗:国际心肺移植学会/器官共享联合网络胸外科登记处的联合分析
J Heart Lung Transplant. 1998 Apr;17(4):374-82.