1977年至1990年期间以色列一家医院分离出的志贺氏菌属中抗菌药物耐药性的发展情况。

Development of antimicrobial drug resistance among Shigellas isolated at an Israeli hospital from 1977 through 1990.

作者信息

Smollan G, Block C

机构信息

Clinical Microbiology Laboratory, Chaim Sheba Medical Center, Tel Hashomer, Israel.

出版信息

Public Health Rev. 1990;18(4):319-27.

PMID:2152154

Abstract

BACKGROUND

Treatment of diarrhea due to Shigella sp. has become complicated in recent years by drug resistance. The emergence of resistance to antibiotics important in the treatment of shigellosis was studied among Shigella sp. isolated at the Sheba Medical Center between 1977 and 1990.

METHOD

A retrospective study of resistance patterns of Shigella sp. using the Kirby-Bauer disc diffusion test.

RESULTS

In the early 1980s S. sonnei replaced S. flexneri as the most frequent isolate. Ampicillin resistance rose steadily, peaking at 70% for S. sonnei in 1990 and 50% for S. flexneri in 1987 and 1990. Resistance to tetracycline roughly paralleled this. By 1990, 68% of S. sonnei and 75% of S. flexneri were insensitive. Cotrimoxazole resistance developed rapidly from 1981. By 1990, 88% of strains of S. sonnei had become resistant, compared to 63% of S. flexneri. S. boydii and S. dysenteriae were encountered less frequently, but showed important rates of resistance. Chloramphenicol remained active against almost all strains of S. sonnei, while resistance in S. flexneri reached about 30% in the late 1980s. Relatively few isolates were resistant to all four drugs. Only 20/841 (2.4%) of strains tested from 1984 to 1990 were resistant to nalidixic acid.

CONCLUSION

The data presented document the emergence of antibiotic resistance as a serious public health problem among strains of Shigella isolated at a large medical center in Israel.

摘要

背景

近年来，由于耐药性，志贺氏菌属引起的腹泻治疗变得复杂。1977年至1990年期间，在舍巴医疗中心分离出的志贺氏菌属中，研究了对志贺氏菌病治疗重要的抗生素耐药性的出现情况。

方法

采用 Kirby-Bauer 纸片扩散法对志贺氏菌属的耐药模式进行回顾性研究。

结果

在20世纪80年代早期，宋内志贺氏菌取代福氏志贺氏菌成为最常见的分离菌株。氨苄西林耐药性稳步上升，1990年宋内志贺氏菌的耐药率达到70%，1987年和1990年福氏志贺氏菌的耐药率达到50%。对四环素的耐药性大致与之平行。到1990年，68%的宋内志贺氏菌和75%的福氏志贺氏菌不敏感。复方新诺明耐药性从1981年开始迅速发展。到1990年，88%的宋内志贺氏菌菌株产生了耐药性，而福氏志贺氏菌为63%。鲍氏志贺氏菌和痢疾志贺氏菌较少见，但显示出重要的耐药率。氯霉素对几乎所有宋内志贺氏菌菌株仍然有效，而在20世纪80年代后期福氏志贺氏菌的耐药率达到约30%。相对较少的分离株对所有四种药物都耐药。1984年至1990年测试的菌株中，只有20/841（2.4%）对萘啶酸耐药。