Institut de Recherche pour le Développement, UMR 216 Mère et enfant face aux infections tropicales, 4 avenue de l'Observatoire, 75006 Paris, France.
Microbes Infect. 2011 Aug;13(8-9):771-5. doi: 10.1016/j.micinf.2011.04.001. Epub 2011 Apr 13.
Clinical protection of Beninese children against Plasmodium falciparum malaria was shown to be influenced by immunoglobulin (IG) Gm and Km allotypes, and related to seroreactivity with the rosette-forming VarO-antigenic variant. IgG to the VarO-infected erythrocyte surface, IgG1 and IgG3 to PfEMP1-NTS-DBL1α(1)-VarO were higher in the under 4-year-old children carrying the Gm 5,6,13,14;1,17 phenotype. In contrast, surface-reactive IgG, total IgG, IgG1 and IgG3 to NTS-DBL1α(1)- and DBL2βC2-VarO domains were lower in the above 4-year-old children harbouring the Km1 allotype. These data outline an age-related association of antibodies against malaria antigens and IG allotype distribution.
贝宁儿童针对恶性疟原虫疟疾的临床保护作用受到免疫球蛋白（IgG）Gm 和 Km 同种异型的影响，并与对形成玫瑰花结的 VarO 抗原变异体的血清反应性相关。携带 Gm 5、6、13、14；1、17 表型的 4 岁以下儿童，针对感染红细胞表面的 VarO、PfEMP1-NTS-DBL1α（1）-VarO 的 IgG1 和 IgG3 更高。相比之下，携带 Km1 同种异型的 4 岁以上儿童，针对 NTS-DBL1α（1）-和 DBL2βC2-VarO 结构域的表面反应性 IgG、总 IgG、IgG1 和 IgG3 较低。这些数据概述了针对疟疾抗原和 IG 同种异型分布的抗体与年龄的相关性。
