Schultz Scot C, Woodward Scott, Ebra George
Gulf Coast Cardiothoracic and Vascular Surgeons, Naples, Florida Naples Community Hospital, Naples, FL, USA.
Heart Surg Forum. 2011 Apr;14(2):E81-6. doi: 10.1532/HSF98.201011115.
At a time when cost containment in health care is under increased scrutiny, coronary artery bypass grafting remains the most widely performed cardiac surgical procedure in the world. This study compares 30-day mortality, morbidity, and resource use for off-pump coronary artery bypass (OPCAB) versus conventional coronary artery bypass (CCAB) revascularization.
From January 2000 through December 2008, 1003 patients underwent OPCAB grafting by a single surgeon (S.C.S.). Data were prospectively collected, entered into a Society of Thoracic Surgeons adult cardiac surgery database, and analyzed retrospectively. We used propensity-matching techniques to match this cohort to a group of 1003 patients who underwent CCAB.
The hospital mortality rate was lower for the OPCAB patients than for the CCAB patients: 2.0% (20/1003) versus 2.8% (28/1003). Predictors of hospital mortality for the entire cohort included age (P = .001), cardiogenic shock (P = .001), congestive heart failure (P = .019), history of myocardial infarction (P = .001), and reoperation (P = .007). The overall incidence of morbidity was lower for the OPCAB patients (reoperation for bleeding, P = .011; prolonged ventilation, P = .035; stroke, P = .045; cardiac arrest, P = .004). OPCAB patients experienced significantly reduced procedure times (P = .001), postoperative ventilation times (P = .035), post-operative lengths of stay (P = .035), and blood product use (intraoperative, P = .001; postoperative, P = .001).
These outcomes clearly demonstrate that OPCAB is a safe and effective procedure for myocardial revascularization. This retrospective, nonrandomized observational study has shown that the patients who underwent OPCAB had reduced morbidity and mortality, as well as decreased resource use, compared with those who underwent CCAB.
在医疗保健成本控制受到越来越多审查的时期,冠状动脉搭桥术仍然是世界上实施最广泛的心脏外科手术。本研究比较了非体外循环冠状动脉搭桥术(OPCAB)与传统冠状动脉搭桥术(CCAB)血运重建的30天死亡率、发病率和资源使用情况。
从2000年1月至2008年12月,1003例患者由单一外科医生(S.C.S.)实施OPCAB移植术。数据前瞻性收集,录入胸外科医师协会成人心脏手术数据库,并进行回顾性分析。我们使用倾向匹配技术将该队列与一组1003例行CCAB的患者进行匹配。
OPCAB患者的医院死亡率低于CCAB患者:2.0%(20/1003)对2.8%(28/1003)。整个队列的医院死亡率预测因素包括年龄(P = .001)、心源性休克(P = .001)、充血性心力衰竭(P = .019)、心肌梗死病史(P = .001)和再次手术(P = .007)。OPCAB患者的总体发病率较低(出血再次手术,P = .011;通气延长,P = .035;中风,P = .045;心脏骤停,P = .004)。OPCAB患者的手术时间(P = .001)、术后通气时间(P = .035)、术后住院时间(P = .035)和血液制品使用量(术中,P = .001;术后,P = .001)显著减少。
这些结果清楚地表明,OPCAB是一种安全有效的心肌血运重建手术。这项回顾性、非随机观察性研究表明,与接受CCAB的患者相比,接受OPCAB的患者发病率和死亡率降低,资源使用也减少。