Lages-Silva E, Filardi L S, Brener Z
Centro de Pesquisas René Rachou, FIOCRUZ, Belo Horizonte, MG, Brasil.
Mem Inst Oswaldo Cruz. 1990 Oct-Dec;85(4):401-5. doi: 10.1590/s0074-02761990000400003.
Single doses of drugs active against Trypanosoma cruzi (megazol, nifurtimox and benznidazole) induce a rapid clearance of the blood parasites in experimentally infected mice. Furthermore, the in vitro phagocytosis and intracellular destruction by mouse peritoneal macrophage of blood forms collected from the treated animals is strongly enhanced as compared with parasites from untreated controls. The uptake of the blood forms by macrophages is significantly higher with megazol than with benznidazole and nifurtimox, a finding that concurs with data showing that megazol is also the most active compound in the living host. The possibility that macrophages participate in a synergic effect between the host immune response and chemotherapeutic effect is discussed.
单剂量的抗克氏锥虫活性药物（美唑、硝呋莫司和苯硝唑）可使实验感染小鼠体内的血液寄生虫迅速清除。此外，与未治疗对照组的寄生虫相比，从经治疗动物采集的血液型态被小鼠腹腔巨噬细胞的体外吞噬作用和细胞内破坏作用显著增强。巨噬细胞对血液型态的摄取，美唑组比苯硝唑组和硝呋莫司组显著更高，这一发现与表明美唑在活体宿主中也是最具活性化合物的数据相符。文中讨论了巨噬细胞参与宿主免疫反应与化疗效果之间协同作用的可能性。
