Kolster J J, Castro de Kolster C, Macía de Luco M
Departamento de Medicina, Universidad de Carabobo, Valencia.
G E N. 1990 Apr-Jun;44(2):118-24.
We compared serum Pepsinogen I (PG I) levels in 25 bleeding duodenal ulcer patients, 25 non bleeding duodenal ulcer (DU) patients and 25 healthy subjects, matched by age and sex. Mean values of PG I in bleeding DU patients were slightly higher than those in non bleeding DU patients, such difference was not statistically significant. Nevertheless, it must be pointed out that 88% of hemorrhagic patients had increased PG I levels compared to 72% of non hemorrhagic patients. The difference between these two groups and the healthy group was highly significant (p < 0.001). We conclude that determination of serum PG I levels is a sensitive complementary diagnostic test in the ulcerous patient. Its capacity, however, to discriminate between bleeding and non bleeding DU patients failed to be found in these study. So, hemorrhage is always a challenge in the natural history of the duodenal ulcer patient.
我们比较了25例十二指肠溃疡出血患者、25例十二指肠溃疡（DU）未出血患者和25例按年龄和性别匹配的健康受试者的血清胃蛋白酶原I（PG I）水平。十二指肠溃疡出血患者的PG I平均值略高于未出血的十二指肠溃疡患者，这种差异无统计学意义。然而，必须指出的是，与72%的未出血患者相比，88%的出血患者PG I水平升高。这两组与健康组之间的差异具有高度统计学意义（p < 0.001）。我们得出结论，血清PG I水平的测定是溃疡患者一种敏感的辅助诊断试验。然而，在本研究中未发现其区分十二指肠溃疡出血和未出血患者的能力。因此，出血始终是十二指肠溃疡患者自然病程中的一个挑战。
