Faraj F J, Lule G N, Mwai J S
East Afr Med J. 1989 Apr;66(4):255-8.
Fasting serum pepsinogen 1 was assayed in 60 patients seen at the Kenyatta National Hospital with endoscopy - confirmed active duodenal ulceration. Pepsinogen 1 values were also correlated with some clinical features and complications of this disorder. 54 (90%) of the patients had significantly elevated values when compared with age and sex matched controls. Although elevated values were found in patients with chronic dyspepsia, family history of ulcer dyspepsia, history of gastro-duodenal blood loss and in patients with virulent ulcers, this did not show statistical significance. The possibility of using serum pepsinogen I to identify duodenal ulcer patients and to predict the clinical course and complications of this disorder is discussed.
对肯尼亚国家医院60例经内镜检查确诊为活动性十二指肠溃疡的患者进行了空腹血清胃蛋白酶原1检测。胃蛋白酶原1值还与该疾病的一些临床特征及并发症相关。与年龄和性别匹配的对照组相比，54例（90%）患者的值显著升高。虽然在慢性消化不良患者、溃疡消化不良家族史患者、胃十二指肠失血史患者以及重症溃疡患者中发现值升高，但这并无统计学意义。本文讨论了使用血清胃蛋白酶原I来识别十二指肠溃疡患者以及预测该疾病临床病程和并发症的可能性。
