Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
Cancer. 2011 May 15;117(10 Suppl):2295-300. doi: 10.1002/cncr.26058.
Every year in Canada and the United States, about 26,000 adolescent and young adults (AYA) between ages 15 and 29 years are diagnosed with cancer. Although the majority of AYA cancer patients will survive their primary cancer, many will develop serious health problems or die prematurely secondary to their curative cancer therapy. Much is known about the long-term health outcomes after adolescent cancer. In contrast, there remain substantial gaps in our understanding of the long-term outcomes after most young adult cancers. To optimize the health and quality of life of AYA cancer survivors and improve upon curative cancer therapy, it is essential to further investigate the long-term outcomes of this population. Before embarking upon this endeavor, it is important for the investigator and the funding agency to be cognizant about some of the unique challenges in research of AYA cancer survivors. To this end, the authors present a brief overview of some of the key research challenges, discuss the strengths and limitations of using available AYA cohorts and databases, and highlight potential future directions.
在加拿大和美国，每年约有 26000 名 15 至 29 岁的青少年和年轻人（AYA）被诊断患有癌症。尽管大多数 AYA 癌症患者会存活下来，但许多人会因治疗癌症的治疗而出现严重的健康问题或过早死亡。人们对青少年癌症的长期健康结果有很多了解。相比之下，对于大多数年轻成年人癌症的长期结果，我们的了解仍然存在很大差距。为了优化 AYA 癌症幸存者的健康和生活质量，并改进治愈性癌症治疗，进一步研究这一人群的长期结果至关重要。在进行这项工作之前，调查人员和资助机构必须认识到研究 AYA 癌症幸存者所面临的一些独特挑战。为此，作者简要概述了一些关键的研究挑战，讨论了使用现有 AYA 队列和数据库的优势和局限性，并强调了潜在的未来方向。
