APP代谢异常的一种新方式可能导致阿尔茨海默病。 - Suppr

Suppr

超能文献

A new way APP mismetabolism can lead to Alzheimer's disease.

作者信息

Hardy John, Guerreiro Rita

机构信息

Reta Lilla Weston Laboratories and Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.

出版信息

EMBO Mol Med. 2011 May;3(5):247-8. doi: 10.1002/emmm.201100139. Epub 2011 Apr 27.

DOI:10.1002/emmm.201100139

PMID:21523909

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3377077/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f75/3377077/acec60f0aab5/emmm0003-0247-f1.jpg

相似文献

A new way APP mismetabolism can lead to Alzheimer's disease.APP代谢异常的一种新方式可能导致阿尔茨海默病。

EMBO Mol Med. 2011 May;3(5):247-8. doi: 10.1002/emmm.201100139. Epub 2011 Apr 27.

Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation.淀粉样前体蛋白突变 E682K 在替代 β-分泌酶切割 β'-位点增加 Aβ 的生成。

EMBO Mol Med. 2011 May;3(5):291-302. doi: 10.1002/emmm.201100138. Epub 2011 Apr 15.

Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence.淀粉样β蛋白前体（APP）中β位点APP裂解酶1（BACE1）裂解位点的替代选择，该APP在Aβ序列内具有保护性和致病性突变。

J Biol Chem. 2016 Nov 11;291(46):24041-24053. doi: 10.1074/jbc.M116.744722. Epub 2016 Sep 29.

Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer's mice.基于瑞典突变体淀粉样前体蛋白（APP）的β-分泌酶1（BACE1）结合位点肽可降低阿尔茨海默病小鼠的APPβ切割及脑内淀粉样β蛋白（Aβ）水平。

Sci Rep. 2015 Jun 19;5:11322. doi: 10.1038/srep11322.

BACE1: from biomarker to Alzheimer's disease therapeutical target.β-分泌酶1：从生物标志物到阿尔茨海默病治疗靶点

Aging (Albany NY). 2021 May 11;13(9):12299-12300. doi: 10.18632/aging.203064.

Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.淀粉样β蛋白（Aβ）Glu11 是β-位淀粉样前体蛋白裂解酶 1（BACE1）的主要β-分泌酶位点，将裂解位点转移到 Aβ Asp1 有助于阿尔茨海默病的发病机制。

Eur J Neurosci. 2013 Jun;37(12):1962-9. doi: 10.1111/ejn.12235.

APP lysine 612 lactylation ameliorates amyloid pathology and memory decline in Alzheimer's disease.淀粉样前体蛋白（APP）赖氨酸612位点的乳酰化改善阿尔茨海默病中的淀粉样病理和记忆衰退。

J Clin Invest. 2025 Jan 2;135(1):e184656. doi: 10.1172/JCI184656.

The role of membrane trafficking in the processing of amyloid precursor protein and production of amyloid peptides in Alzheimer's disease.膜转运在阿尔茨海默病中淀粉样前体蛋白加工和淀粉样肽产生中的作用。

Biochim Biophys Acta Biomembr. 2019 Apr 1;1861(4):697-712. doi: 10.1016/j.bbamem.2018.11.013. Epub 2019 Jan 11.

The β-Secretase Enzyme BACE1: A Biochemical Enigma for Alzheimer's Disease.β-分泌酶酶 1（BACE1）：阿尔茨海默病的生化之谜。

CNS Neurol Disord Drug Targets. 2020;19(3):184-194. doi: 10.2174/1871527319666200526144141.

The secretases of Alzheimer's disease.阿尔茨海默病的分泌酶

Curr Top Dev Biol. 2003;54:233-61. doi: 10.1016/s0070-2153(03)54011-x.

引用本文的文献

, and Mutations in Asian Patients with Early-Onset Alzheimer Disease.携带 PSEN1、PSEN2 和 APP 突变的早发性阿尔茨海默病亚洲患者。

Int J Mol Sci. 2019 Sep 25;20(19):4757. doi: 10.3390/ijms20194757.

Protein fragments: functional and structural roles of their coevolution networks.蛋白质片段：它们共进化网络的功能和结构作用。

PLoS One. 2012;7(11):e48124. doi: 10.1371/journal.pone.0048124. Epub 2012 Nov 5.

本文引用的文献

Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP.对伊比利亚和非洲样本中的阿尔茨海默病基因进行遗传筛查，发现早老素和 APP 中的新突变。

Neurobiol Aging. 2010 May;31(5):725-31. doi: 10.1016/j.neurobiolaging.2008.06.012. Epub 2008 Jul 30.

APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy.APP基因座重复导致常染色体显性遗传的早发性阿尔茨海默病伴脑淀粉样血管病。

Nat Genet. 2006 Jan;38(1):24-6. doi: 10.1038/ng1718. Epub 2005 Dec 20.

Biochemical and kinetic characterization of BACE1: investigation into the putative species-specificity for beta- and beta'-cleavage sites by human and murine BACE1.β-分泌酶1（BACE1）的生化与动力学特性：对人源和鼠源BACE1在β-和β'-切割位点假定的物种特异性的研究。

J Neurochem. 2004 Dec;91(6):1249-59. doi: 10.1111/j.1471-4159.2004.02764.x.

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.阿尔茨海默病的淀粉样蛋白假说：治疗之路上的进展与问题

Science. 2002 Jul 19;297(5580):353-6. doi: 10.1126/science.1072994.

Flemish and Dutch mutations in amyloid beta precursor protein have different effects on amyloid beta secretion.淀粉样前体蛋白中的佛兰芒语和荷兰语突变对β淀粉样蛋白分泌有不同影响。

Neurobiol Dis. 1998 Oct;5(4):281-6. doi: 10.1006/nbdi.1998.0202.

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.与阿尔茨海默病老年斑中相似的分泌型淀粉样β蛋白，在体内会因与家族性阿尔茨海默病相关的早老素1和2以及APP突变而增加。

Nat Med. 1996 Aug;2(8):864-70. doi: 10.1038/nm0896-864.

Generation of amyloid beta protein from its precursor is sequence specific.由其前体生成β淀粉样蛋白具有序列特异性。

Neuron. 1995 Mar;14(3):661-70. doi: 10.1016/0896-6273(95)90323-2.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验