BACE1: from biomarker to Alzheimer's disease therapeutical target.
作者信息
Cervellati Carlo, Valacchi Giuseppe, Zuliani Giovanni
机构信息
Department of Translational Medicine and for Romagna, University of Ferrara, Ferrara, 44121, Italy.
Department of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, 44121, Italy.
出版信息
Aging (Albany NY). 2021 May 11;13(9):12299-12300. doi: 10.18632/aging.203064.
Abstract
摘要
相似文献
1
BACE1: from biomarker to Alzheimer's disease therapeutical target.
Aging (Albany NY). 2021 May 11;13(9):12299-12300. doi: 10.18632/aging.203064.
2
The β-Secretase Enzyme BACE1: A Biochemical Enigma for Alzheimer's Disease.
CNS Neurol Disord Drug Targets. 2020;19(3):184-194. doi: 10.2174/1871527319666200526144141.
3
Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence.
J Biol Chem. 2016 Nov 11;291(46):24041-24053. doi: 10.1074/jbc.M116.744722. Epub 2016 Sep 29.
4
Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer's mice.
Sci Rep. 2015 Jun 19;5:11322. doi: 10.1038/srep11322.
5
BACE1 SUMOylation deregulates phosphorylation and ubiquitination in Alzheimer's disease pathology.
J Neurochem. 2023 Jul;166(2):318-327. doi: 10.1111/jnc.15870. Epub 2023 Jun 7.
6
Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models.
Neurobiol Dis. 2016 Jan;85:187-205. doi: 10.1016/j.nbd.2015.11.005. Epub 2015 Nov 10.
7
The role of membrane trafficking in the processing of amyloid precursor protein and production of amyloid peptides in Alzheimer's disease.
Biochim Biophys Acta Biomembr. 2019 Apr 1;1861(4):697-712. doi: 10.1016/j.bbamem.2018.11.013. Epub 2019 Jan 11.
8
MiR-340 Reduces the Accumulation of Amyloid-β Through Targeting BACE1 (β-site Amyloid Precursor Protein Cleaving Enzyme 1) in Alzheimer's Disease.
Curr Neurovasc Res. 2020;17(1):86-92. doi: 10.2174/1567202617666200117103931.
9
Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
Eur J Neurosci. 2013 Jun;37(12):1962-9. doi: 10.1111/ejn.12235.
10
A new way APP mismetabolism can lead to Alzheimer's disease.
EMBO Mol Med. 2011 May;3(5):247-8. doi: 10.1002/emmm.201100139. Epub 2011 Apr 27.
引用本文的文献
1
The manipulator behind "Scissors": γ -secretase and its modulators in Alzheimer's disease.
Front Aging Neurosci. 2025 Aug 25;17:1637671. doi: 10.3389/fnagi.2025.1637671. eCollection 2025.
2
Reducing Nogo-B Improves Hepatic Fibrosis by Inhibiting BACe1-Mediated Autophagy.
Tissue Eng Regen Med. 2024 Jul;21(5):777-789. doi: 10.1007/s13770-024-00641-5. Epub 2024 Apr 17.
3
Discerning the Prospects of miRNAs as a Multi-Target Therapeutic and Diagnostic for Alzheimer's Disease.
Mol Neurobiol. 2023 Oct;60(10):5954-5974. doi: 10.1007/s12035-023-03446-0. Epub 2023 Jun 29.
4
Increased Serum Beta-Secretase 1 Activity is an Early Marker of Alzheimer's Disease.
J Alzheimers Dis. 2022;87(1):433-441. doi: 10.3233/JAD-215542.
本文引用的文献
1
The validation status of blood biomarkers of amyloid and phospho-tau assessed with the 5-phase development framework for AD biomarkers.
Eur J Nucl Med Mol Imaging. 2021 Jul;48(7):2140-2156. doi: 10.1007/s00259-021-05253-y. Epub 2021 Mar 6.
2
Plasma β-secretase1 concentrations correlate with basal forebrain atrophy and neurodegeneration in cognitively healthy individuals at risk for AD.
Alzheimers Dement. 2021 Apr;17(4):629-640. doi: 10.1002/alz.12228. Epub 2021 Feb 1.
3
Increased blood BACE1 activity as a potential common pathogenic factor of vascular dementia and late onset Alzheimer's disease.
Sci Rep. 2020 Sep 11;10(1):14980. doi: 10.1038/s41598-020-72168-3.
4
Is It the Twilight of BACE1 Inhibitors?
Curr Neuropharmacol. 2021;19(1):61-77. doi: 10.2174/1570159X18666200503023323.
5
The β-Secretase BACE1 in Alzheimer's Disease.
Biol Psychiatry. 2021 Apr 15;89(8):745-756. doi: 10.1016/j.biopsych.2020.02.001. Epub 2020 Feb 13.
6
Serum beta-secretase 1 (BACE1) activity as candidate biomarker for late-onset Alzheimer's disease.
Geroscience. 2020 Feb;42(1):159-167. doi: 10.1007/s11357-019-00127-6. Epub 2019 Nov 19.
7
Alzheimer's disease drug development pipeline: 2019.
Alzheimers Dement (N Y). 2019 Jul 9;5:272-293. doi: 10.1016/j.trci.2019.05.008. eCollection 2019.
8
Amyloid precursor protein processing and Alzheimer's disease.
Annu Rev Neurosci. 2011;34:185-204. doi: 10.1146/annurev-neuro-061010-113613.
Zotero 插件