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BACE1: from biomarker to Alzheimer's disease therapeutical target.

作者信息

Cervellati Carlo, Valacchi Giuseppe, Zuliani Giovanni

机构信息

Department of Translational Medicine and for Romagna, University of Ferrara, Ferrara, 44121, Italy.

Department of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, 44121, Italy.

出版信息

Aging (Albany NY). 2021 May 11;13(9):12299-12300. doi: 10.18632/aging.203064.

DOI:10.18632/aging.203064
PMID:33982671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8148506/
Abstract
摘要

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本文引用的文献

1
The validation status of blood biomarkers of amyloid and phospho-tau assessed with the 5-phase development framework for AD biomarkers.采用 AD 生物标志物 5 阶段开发框架评估淀粉样蛋白和磷酸化 tau 血液生物标志物的验证状态。
Eur J Nucl Med Mol Imaging. 2021 Jul;48(7):2140-2156. doi: 10.1007/s00259-021-05253-y. Epub 2021 Mar 6.
2
Plasma β-secretase1 concentrations correlate with basal forebrain atrophy and neurodegeneration in cognitively healthy individuals at risk for AD.血浆β-分泌酶 1 浓度与 AD 高危认知健康个体的基底前脑萎缩和神经退行性变相关。
Alzheimers Dement. 2021 Apr;17(4):629-640. doi: 10.1002/alz.12228. Epub 2021 Feb 1.
3
Increased blood BACE1 activity as a potential common pathogenic factor of vascular dementia and late onset Alzheimer's disease.血液 BACE1 活性升高可能是血管性痴呆和迟发性阿尔茨海默病的共同潜在致病因素。
Sci Rep. 2020 Sep 11;10(1):14980. doi: 10.1038/s41598-020-72168-3.
4
Is It the Twilight of BACE1 Inhibitors?β-分泌酶1（BACE1）抑制剂的黄昏时刻来临了吗？
Curr Neuropharmacol. 2021;19(1):61-77. doi: 10.2174/1570159X18666200503023323.
5
The β-Secretase BACE1 in Alzheimer's Disease.阿尔茨海默病中的β-分泌酶 BACE1。
Biol Psychiatry. 2021 Apr 15;89(8):745-756. doi: 10.1016/j.biopsych.2020.02.001. Epub 2020 Feb 13.
6
Serum beta-secretase 1 (BACE1) activity as candidate biomarker for late-onset Alzheimer's disease.血清β-分泌酶 1（BACE1）活性作为迟发性阿尔茨海默病的候选生物标志物。
Geroscience. 2020 Feb;42(1):159-167. doi: 10.1007/s11357-019-00127-6. Epub 2019 Nov 19.
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Amyloid precursor protein processing and Alzheimer's disease.淀粉样前体蛋白的加工与阿尔茨海默病。
Annu Rev Neurosci. 2011;34:185-204. doi: 10.1146/annurev-neuro-061010-113613.