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Thrombotic thrombocytopenic purpura in IgG4-related disease with severe deficiency of ADAMTS-13 activity and IgG4 autoantibody against ADAMTS-13.

作者信息

Saeki Takako, Ito Tomoyuki, Youkou Akira, Ishiguro Hajime, Sato Naoko, Yamazaki Hajime, Koike Tadashi, Kourakata Hiroyo, Ferrari Silvia, Scheiflinger Friedrich, Narita Ichiei

机构信息

Department of Internal Medicine, Nagaoka Red Cross Hospital,2-297-1 Senshu, Nagaoka, Niigata, Japan.

出版信息

Arthritis Care Res (Hoboken). 2011 Aug;63(8):1209-12. doi: 10.1002/acr.20484.

DOI:10.1002/acr.20484
PMID:21523922
Abstract
摘要

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Thrombotic thrombocytopenic purpura in IgG4-related disease with severe deficiency of ADAMTS-13 activity and IgG4 autoantibody against ADAMTS-13.IgG4相关疾病伴严重ADAMTS-13活性缺乏及抗ADAMTS-13 IgG4自身抗体的血栓性血小板减少性紫癜
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A 9-month-old infant with acquired idiopathic thrombotic thrombocytopenic purpura caused by inhibitory IgG-autoantibody to ADAMTS13.一名9个月大的婴儿，患有由针对ADAMTS13的抑制性IgG自身抗体引起的获得性特发性血栓性血小板减少性紫癜。
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Inhibitory autoantibodies against ADAMTS-13 in patients with thrombotic thrombocytopenic purpura bind ADAMTS-13 protease and may accelerate its clearance in vivo.血栓性血小板减少性紫癜患者体内针对ADAMTS - 13的抑制性自身抗体可结合ADAMTS - 13蛋白酶，并可能在体内加速其清除。
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Front Immunol. 2022 Jan 14;12:785247. doi: 10.3389/fimmu.2021.785247. eCollection 2021.
2
Case Report: Severe Complement-Mediated Thrombotic Microangiopathy in IgG4-Related Disease Secondary to Anti-Factor H IgG4 Autoantibodies.病例报告：抗补体因子 H IgG4 自身抗体导致 IgG4 相关疾病继发严重补体介导的血栓性微血管病。
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Arch Rheumatol. 2018 Nov 30;34(3):343-347. doi: 10.5606/ArchRheumatol.2019.7070. eCollection 2019 Sep.
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J Autoimmun. 2016 Sep;73:111-9. doi: 10.1016/j.jaut.2016.06.019. Epub 2016 Jul 1.