Turakulov Ia Kh, Salakhova N S, Tashkhodzhaeva T P, Mirmakhmudova S I, Mullagalieva N M
Biull Eksp Biol Med. 1978 Dec;86(12):653-5.
The influence of potassium iodide and perchlorate on the parameters characterizing the thypoid hormones secretion, such as the cAMP level in the gland tissue and the number of intracellular colloid droplets under condition of stimulation by thyrotropic hormone was studied. It was shown that the abovementioned parameters were depressed by an excess of iodide, but perchlorate administration prevented the inhibitory effect of iodide. The results obtained favour the conception on the sensitivity of the thyroid adenylate cyclase system to the organic iodine concentration. Apparently and excess of iodide depressed the capacity of perchlorate to influence its concentration in the gland, and thereby the process of iodine organification and of the thyroid hormone secretion maintained at the optimal leve.
研究了碘化钾和高氯酸盐对表征甲状腺激素分泌的参数的影响，这些参数如在促甲状腺激素刺激条件下腺组织中的环磷酸腺苷（cAMP）水平和细胞内胶体滴的数量。结果表明，过量的碘化物会降低上述参数，但给予高氯酸盐可防止碘化物的抑制作用。所得结果支持甲状腺腺苷酸环化酶系统对有机碘浓度敏感的观点。显然，过量的碘化物降低了高氯酸盐影响其在腺体中浓度的能力，从而使碘的有机化过程和甲状腺激素分泌过程维持在最佳水平。
