Nilbert M, Jin Y S, Heim S, Mandahl N, Flodérus U M, Willén H, Mitelman F
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Cancer Genet Cytogenet. 1990 Jan;44(1):27-35. doi: 10.1016/0165-4608(90)90194-f.
Cytogenetic analysis of short-term cultures from two uterine sarcomas revealed clonal chromosome abnormalities in both cases. A locally recurrent mixed mesodermal tumor had the karyotype 61,XX,+2,+3,+del(5)(q11),+6,+7,+del(7)(q32),+8,+8,+8,+10, -11,-11,+der(11)t(1;11)(q12;p15),+der(11)t(1;11)(q12;p15),+der(11)t(1;11)(q12;p15),+del(12)(q14q21),+13,+15,del(17)(q23),+20. The other tumor, a lung metastasis from a uterine leiomyosarcoma, had several karyotypically abnormal clones. Two of them consisted of highly aberrant cells with modal chromosome numbers of 82 and 153, respectively, but because of insufficient quality the complex anomalies could not be identified. Various chromosomal changes that included translocations, deletions, insertions, and numerical rearrangements (always with extra chromosome 7 material) were identified in pseudo- or near-diploid cells, resulting in nine additional cytogenetically abnormal clones.
对来自两个子宫肉瘤的短期培养物进行细胞遗传学分析，结果显示两例均存在克隆性染色体异常。一例局部复发性混合性中胚层肿瘤的核型为61,XX,+2,+3,+del(5)(q11),+6,+7,+del(7)(q32),+8,+8,+8,+10,-11,-11,+der(11)t(1;11)(q12;p15),+der(11)t(1;11)(q12;p15),+der(11)t(1;11)(q12;p15),+del(12)(q14q21),+13,+15,del(17)(q23),+20。另一例肿瘤是子宫平滑肌肉瘤的肺转移灶，有几个核型异常的克隆。其中两个克隆由高度异常的细胞组成，其众数染色体数分别为82和153，但由于质量不佳，无法识别复杂的异常情况。在假二倍体或近二倍体细胞中发现了各种染色体变化，包括易位、缺失、插入和数目重排（总是伴有额外的7号染色体物质），从而产生了另外9个细胞遗传学异常的克隆。
