红斑狼疮中的辅助性T细胞17细胞群。
T helper 17 cell population in lupus erythematosus.
作者信息
Bălănescu P, Bălănescu Eugenia, Tănăsescu C, Nicolau Adriana, Tănăsescu R, Grancea Camelia, Vagu Codruţa, Ruţă Simona, Bleoţu Coralia
机构信息
Colentina Clinical Hospital, Bucharest, Romania.
出版信息
Rom J Intern Med. 2010;48(3):255-9.
UNLABELLED
Lupus erythematosus (LE) is an autoimmune inflammatory disease that involves many organs and systems. Immunological factors seem to play a key-role in LE pathogenesis. LE patients have T lymphocytes dysfunctions.Th17 is implicated in the pathogenesis of various autoimmune diseases like psoriasis, multiple sclerosis or rheumatoid arthritis. The purpose of this study was to evaluate the circulating Th17 cell population in LE patients.
MATERIAL AND METHODS
A total of 15 LE patients were recruited and divided into three groups: systemic lupus erythematosus (SLE), discoid lupus (DLE) and subacute lupus (SCLE). Serum IL-17A, IL-17F and IL-23 were detected. Th17 circulating cells were evaluated by flow cytometry.
RESULTS
Serum IL-17A and IL-17F levels were higher in SLE, DLE and SCLE patients compared to healthy controls. The number of Th17 cells were higher in SLE and DLE patients (p<0.05). the number of CD3+IL-17+ cells were higher in SLE, DLE and SCLE patients (p<0.05).
CONCLUSION
Th17 lymphocytes are implicated in LE pathogenesis. Our findings suggest that IL-17 is implicated not only in SLE but also in DLE and SCLE immunopathogenesis.
未标注
红斑狼疮（LE）是一种涉及多个器官和系统的自身免疫性炎症性疾病。免疫因素似乎在LE发病机制中起关键作用。LE患者存在T淋巴细胞功能障碍。Th17与多种自身免疫性疾病如银屑病、多发性硬化症或类风湿性关节炎的发病机制有关。本研究的目的是评估LE患者循环中Th17细胞群体。
材料与方法
共招募了15例LE患者，分为三组：系统性红斑狼疮（SLE）、盘状红斑狼疮（DLE）和亚急性红斑狼疮（SCLE）。检测血清IL-17A、IL-17F和IL-23。通过流式细胞术评估循环中的Th17细胞。
结果
与健康对照相比，SLE、DLE和SCLE患者血清IL-17A和IL-17F水平更高。SLE和DLE患者的Th17细胞数量更高（p<0.05）。SLE、DLE和SCLE患者的CD3+IL-17+细胞数量更高（p<0.05）。
结论
Th17淋巴细胞与LE发病机制有关。我们的研究结果表明，IL-17不仅与SLE有关，还与DLE和SCLE的免疫发病机制有关。
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