Thomas D B, Rawls W E
Cancer. 1978 Dec;42(6):2716-25. doi: 10.1002/1097-0142(197812)42:6<2716::aid-cncr2820420629>3.0.co;2-1.
Serum specimens from 75 women with cervical carcinoma in situ, 84 with squamous dysplasia, and 132 controls, who had previously been interviewed and tested for complement fixing antibodies against a number of organisms, were analyzed for HSV-2 antibodies. Carcinoma in situ and severe dysplasia were associated with HSV-2 antibodies. Mild dysplasia was related to evidence of prior infection by Trichomonas vaginalis, adenoviruses, and Mycoplasma pneumoniae, plus a history of vaginal discharge. Severe dysplasia was less strongly related to these variables. The relative risk of dysplasia increased with the number of different pathogens by which a woman had been infected. It is concluded that HSV-2 may be a cause of carcinoma in situ; that much dysplasia is a nonspecific reaction of the cervical epithelium to chronic inflammation; and that dysplastic lesions that are caused by HSV-2, and hence may be a precursor to carcinoma in situ, tend to be distinguished by their severity.
对75例原位宫颈癌患者、84例鳞状上皮发育异常患者以及132名对照者的血清样本进行了分析，检测其中的单纯疱疹病毒2型（HSV - 2）抗体。这些患者此前已接受访谈，并检测了针对多种病原体的补体结合抗体。原位癌和重度发育异常与HSV - 2抗体有关。轻度发育异常与先前感染阴道毛滴虫、腺病毒和肺炎支原体的证据以及白带病史有关。重度发育异常与这些变量的相关性较弱。发育异常的相对风险随着女性感染的不同病原体数量的增加而升高。得出的结论是，HSV - 2可能是原位癌的一个病因；许多发育异常是宫颈上皮对慢性炎症的非特异性反应；由HSV - 2引起的发育异常病变，因此可能是原位癌的前兆，往往因其严重程度而有所区别。
