Dale G E, Coleman R M, Best J M, Benetato B B, Drew N C, Chinn S, Papacosta A O, Nahmias A J
Department of Virology, United Medical School of Guy's Hospital, London, England.
Epidemiol Infect. 1988 Jun;100(3):445-65. doi: 10.1017/s0950268800067194.
Serum and cervical secretions were collected from patients with cervical dysplasia, carcinoma-in-situ (CIS), squamous cell carcinoma (cervical SCC), and controls with normal cervices, attending clinics within the West Lambeth Health District, London. Enzyme-linked immunosorbent assays were used to examine cervical secretory IgA (sIgA) and serum IgG and IgA antibodies to herpes simplex virus (HSV). Sexual and demographic factors were considered during data analysis, which involved fitting multiple linear or multiple logistic regressions to HSV antibody levels. Prevalence of sIgA-HSV and levels of serum antibodies to HSV in all groups were compared with those of gynaecology controls. Caucasian women with mild dysplasia had a significantly higher prevalence of sIgA-HSV. Serum IgG levels to HSV (IgG-HSV) were significantly elevated in women with mild dysplasia and severe dysplasia/CIS. Serum IgA levels to HSV1 (IgG-HSV1) were significantly higher in women with cervical SCC (after adjusting for smoking habits) and other genital tumours. Significantly higher levels of serum IgA to HSV2 (IgA-HSV2) were also found among Caucasian women with cervical SCC. The possible role of HSV as a co-factor in cervical carcinogenesis is discussed.
从伦敦西兰贝斯健康区各诊所就诊的宫颈发育异常、原位癌（CIS）、鳞状细胞癌（宫颈鳞癌）患者以及宫颈正常的对照者中采集血清和宫颈分泌物。采用酶联免疫吸附测定法检测宫颈分泌型IgA（sIgA）以及针对单纯疱疹病毒（HSV）的血清IgG和IgA抗体。数据分析过程中考虑了性和人口统计学因素，这涉及对HSV抗体水平进行多元线性或多元逻辑回归分析。将所有组中sIgA-HSV的患病率以及HSV血清抗体水平与妇科对照者进行比较。患有轻度发育异常的白人女性中sIgA-HSV的患病率显著更高。患有轻度发育异常和重度发育异常/CIS的女性中，HSV的血清IgG水平（IgG-HSV）显著升高。患有宫颈鳞癌（校正吸烟习惯后）和其他生殖器肿瘤的女性中，HSV1的血清IgA水平（IgG-HSV1）显著更高。在患有宫颈鳞癌的白人女性中也发现HSV2的血清IgA水平（IgA-HSV2）显著更高。文中讨论了HSV作为宫颈癌发生辅助因子的可能作用。
