Longaker M T, Adzick N S, Sadigh D, Hendin B, Stair S E, Duncan B W, Harrison M R, Spendlove R, Stern R
Department of Surgery, School of Medicine, University of California, San Francisco 94143-0506.
J Natl Cancer Inst. 1990 Jan 17;82(2):135-9. doi: 10.1093/jnci/82.2.135.
Markedly elevated levels of hyaluronic acid occur in the serum and urine of some patients with Wilms' tumor. We have recently described a glycoprotein factor in fetal serum that stimulates deposition of hyaluronic acid. In a survey of bovine fetal tissue extracts, we have identified the fetal kidney as the source of this circulating activity. Wilms' tumors arise from transformed "rests" of fetal kidney. We demonstrate here that such tumors continue to produce this fetal factor and that the hyaluronic acid-stimulating activity is found in the urine of children with Wilms' tumors. In the three patients with Wilms' tumor who were followed, elevated levels of hyaluronic acid-stimulating activity were found in their urine before treatment. By 2 months after surgical removal of their tumors, these levels had returned to baseline. We propose that hyaluronic acid-stimulating activity is the mechanism for the elevated levels of hyaluronic acid in the sera and urine of these patients. The activity is an oncofetal protein and the first for which a function has been identified. It also is a marker for this common childhood solid tumor and has the potential for identifying children at increased risk.
一些患有肾母细胞瘤的患者血清和尿液中透明质酸水平显著升高。我们最近在胎儿血清中描述了一种刺激透明质酸沉积的糖蛋白因子。在对牛胎儿组织提取物的调查中，我们确定胎儿肾脏是这种循环活性的来源。肾母细胞瘤起源于胎儿肾脏的转化“残体”。我们在此证明，此类肿瘤会持续产生这种胎儿因子，并且在患有肾母细胞瘤儿童的尿液中发现了透明质酸刺激活性。在随访的3例肾母细胞瘤患者中，治疗前其尿液中透明质酸刺激活性水平升高。在手术切除肿瘤2个月后，这些水平恢复到基线。我们提出，透明质酸刺激活性是这些患者血清和尿液中透明质酸水平升高的机制。该活性是一种癌胚蛋白，也是首个已确定功能的此类蛋白。它还是这种常见儿童实体瘤的标志物，具有识别风险增加儿童的潜力。
