Brigham B A, Bunn P A, Minna J D, Cohen M H, Ihde D C, Shackney S E
Cancer. 1978 Dec;42(6):2880-6. doi: 10.1002/1097-0142(197812)42:6<2880::aid-cncr2820420650>3.0.co;2-x.
In reviewing a series of 144 patients with small cell bronchogenic carcinoma, 12 were found to have serially measurable roentgenographic lesions prior to therapy. Although caliper-based measurements and a silhouette cutout method gave comparable sets of tumor doubling time data, inter-observer variability was less with the silhouette cutout method. Tumor doubling times in small cell bronchogenic carcinoma ranged between 25 and 160 days, with a median of 77 days, a log mean of 81 days, and an arithmetic mean of 91 days. There was no apparent relation between tumor doubling time and tumor location, histologic subtype, response to therapy, or patient survival. The data indicate that small cell bronchogenic carcinoma of the lung is a relatively slowly growing tumor. Assuming that late subclinical disease exhibits growth characteristics that are similar to those seen in the clinical stages of growth, it can be estimated that residual body tumor burdens of 1 X 10(6) cells may be followed by tumor recurrence times of 2 years or longer; the likelihood of "cure" should not be entertained in patients with disease-free intervals shorter than 4-5 years.
在回顾144例小细胞支气管肺癌患者时，发现12例在治疗前有可连续测量的X线病变。尽管基于卡尺的测量方法和剪影剪裁法得出了可比的肿瘤倍增时间数据集，但剪影剪裁法的观察者间变异性较小。小细胞支气管肺癌的肿瘤倍增时间在25至160天之间，中位数为77天，对数均值为81天，算术均值为91天。肿瘤倍增时间与肿瘤位置、组织学亚型、对治疗的反应或患者生存率之间没有明显关系。数据表明，肺小细胞支气管肺癌是一种生长相对缓慢的肿瘤。假设晚期亚临床疾病的生长特征与临床生长阶段相似，可以估计，残留体内肿瘤负荷为1×10⁶个细胞时，肿瘤复发时间可能为2年或更长；无病间期短于4至5年的患者不应抱有“治愈”的期望。
