Shapiro S, Tatakis D N, Dziak R
SUNY-Buffalo, School of Dental Medicine, Department of Oral Biology 14214.
Calcif Tissue Int. 1990 Jan;46(1):60-2. doi: 10.1007/BF02555826.
Tumor necrosis factor alpha (10(-10) - 10(-8) M) had no effects on cyclic AMP production by the osteoblastic osteosarcomal cells, Saos-2 and G292, or normal rat calvarial cells. The cytokine did, however, inhibit the parathyroid hormone (PTH)-induced effect on cyclic AMP in the Saos-2 and normal rat osteoblastic cells. This inhibitory effect did not occur on prostaglandin E2-induced cyclic AMP increases in the osteoblastic cells. Interleukin-1 (10 U/ml-100 U/ml) did not produce any effect on basal levels or PTH-induced cyclic AMP increases in these cells.
肿瘤坏死因子α（10⁻¹⁰ - 10⁻⁸M）对成骨细胞性骨肉瘤细胞Saos-2和G292或正常大鼠颅骨细胞的环磷酸腺苷生成没有影响。然而，该细胞因子确实抑制了甲状旁腺激素（PTH）对Saos-2和正常大鼠成骨细胞中环磷酸腺苷的诱导作用。这种抑制作用在成骨细胞中前列腺素E2诱导的环磷酸腺苷增加中并未出现。白细胞介素-1（10 U/ml - 100 U/ml）对这些细胞的基础水平或PTH诱导的环磷酸腺苷增加没有任何影响。
