Department of Social and Environmental Health Research, London School of Hygiene & Tropical Medicine, 15-17 Tavistock Place, London WC1H 9SH, United Kingdom.
Departments of Environmental Health Sciences and Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, Rensselaer, New York, NY 12114, United States.
Reprod Toxicol. 2012 Jul;33(4):552-555. doi: 10.1016/j.reprotox.2011.04.002. Epub 2011 Apr 17.
Results from animal studies have shown that negative associations between serum levels of free thyroxine (FT4) and perfluorooctane sulfonate (PFOS) at concentrations much higher than those reported for any exposed population may be due to bias in analog methods used for measuring FT4. We aimed to assess if there is evidence of differences between human FT4 measurements in serum by an analog and a dialysis method due to the presence of PFOS or perfluorooctanoate (PFOA) in a population of 50 adults with typical US serum PFOS concentrations but higher PFOA concentrations. Mean analog-dialysis difference was -0.02 (95% CI=-0.06, 0.02). Regressing the difference between FT4 measurements on either PFOA or PFOS serum concentrations yielded slopes close to zero. The present findings do not indicate any observable bias from the use of the analog with respect to the dialysis method, across the range of PFOS and PFOA concentrations in this population.
动物研究的结果表明，在浓度远高于任何暴露人群报告的浓度下，血清游离甲状腺素（FT4）水平与全氟辛烷磺酸（PFOS）之间的负相关可能是由于用于测量 FT4 的模拟方法存在偏差。我们旨在评估在一个具有典型美国血清 PFOS 浓度但更高 PFOA 浓度的 50 名成年人中，由于存在 PFOS 或全氟辛酸（PFOA），是否存在由于模拟和透析方法测量人血清 FT4 之间存在差异的证据。模拟-透析差值的平均值为-0.02（95%CI=-0.06，0.02）。将 FT4 测量值之间的差异与 PFOA 或 PFOS 血清浓度进行回归，得到的斜率接近零。本研究结果表明，在该人群的 PFOS 和 PFOA 浓度范围内，与透析方法相比，使用模拟方法不存在可观察到的偏差。
