Endocrine Toxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, United States.
Reprod Toxicol. 2011 Jul;32(1):52-63. doi: 10.1016/j.reprotox.2011.04.003. Epub 2011 Apr 17.
Few studies have investigated the long-term effects of atrazine (ATR) following in utero exposure. We evaluated the effects of gestational exposure of Sprague Dawley dams to ATR (0, 1, 5, 20, or 100mg/kg-d) on the reproductive development of male offspring. We also quantified the distribution of ATR and its chlorinated metabolites in maternal, fetal, and neonatal fluid and tissue samples following gestational and/or lactational exposure. Dose-dependent levels of chlorotriazines, primarily diamino-s-chlorotriazine, were present in most samples analyzed, including fetal tissue. In utero exposure to 1-20mg/kg-d ATR did not alter testosterone production, the timing of puberty, play behavior, or other androgen-dependent endpoints of male offspring. Significant maternal toxicity and postnatal mortality were observed at 100mg/kg-d. We conclude that, although levels of chlorotriazines within the fetus were considerable, gestational exposures of 1-20mg/kg-d do not lead to alterations in the measures of male development examined in this study.
很少有研究调查过孕期暴露于莠去津（ATR）后的长期影响。我们评估了妊娠暴露于 ATR（0、1、5、20 或 100mg/kg-d）对雄性后代生殖发育的影响。我们还定量分析了母体、胎儿和新生儿液体制品和组织样本中 ATR 及其氯化代谢物在妊娠和/或哺乳期暴露后的分布。在大多数分析样本中，包括胎儿组织中，都存在依赖剂量的氯三嗪，主要是二氨基-s-氯三嗪。雄性后代的睾丸酮生成、青春期出现时间、玩耍行为或其他雄激素依赖终点在妊娠期间暴露于 1-20mg/kg-d ATR 后并未改变。在 100mg/kg-d 时观察到明显的母体毒性和新生儿死亡率。我们的结论是，尽管胎儿内的氯三嗪水平相当高，但在本研究中，妊娠期间暴露于 1-20mg/kg-d 不会导致雄性发育测量值的改变。
