Endocrine Toxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
Reprod Toxicol. 2011 Jul;32(1):43-51. doi: 10.1016/j.reprotox.2011.04.004. Epub 2011 Apr 20.
Atrazine (ATR) is an herbicide that exerts negative reproductive effects. We examined the effects of vehicle or ATR (1, 5, 20 and 100mg/kg-d), administered to Sprague-Dawley rats on gestational days 14-21, once daily or divided into two doses per day, on female offspring reproductive indices. Offspring body weights at birth were reduced and mortality increased in the 100mg/kg-d group shortly after birth; by PND 21 there were no significant effects. Vaginal opening was delayed in this group, indicating delayed puberty. No significant differences in mammary gland development were apparent at PND 45, or estrous cyclicity through PND 272. There were no differences between dosing regimens. Lower ATR doses (0-20mg/kg-d) showed few effects in females prenatally exposed to ATR, while the high dose (100mg/kg-d) reduced offspring body weight and delayed vaginal opening. Nonetheless, it is unlikely that environmental exposure comparable to the high dose would be encountered.
莠去津（ATR）是一种除草剂，具有负面的生殖效应。我们研究了妊娠第 14-21 天的 Sprague-Dawley 大鼠每天接受一次或分为两次接受ATR（1、5、20 和 100mg/kg-d），以及车辆对照处理对雌性后代生殖指数的影响。在出生后不久的 100mg/kg-d 组中，后代的体重降低且死亡率增加；在 PND21 时没有明显影响。该组的阴道开口延迟，表明青春期延迟。在 PND45 时，乳腺发育没有明显差异，也没有明显的发情周期变化到 PND272。两种剂量方案之间没有差异。在产前暴露于 ATR 的雌性中，较低的 ATR 剂量（0-20mg/kg-d）显示出很少的影响，而高剂量（100mg/kg-d）则降低了后代的体重并延迟了阴道开口。然而，不太可能遇到与高剂量相当的环境暴露。
