Banks D E, Rando R J, Barkman H W
Department of Medicine, Tulane University School of Medicine, New Orleans, LA.
Chest. 1990 Jan;97(1):121-5. doi: 10.1378/chest.97.1.121.
Six polyurethane foam workers were shown to have TDI-induced asthma by specific inhalation challenge testing. All remained in the workplace in jobs with minimal TDI exposures. Mean and time-weighted average exposure concentration for the asthmatic group was 0.64 +/- 0.46 ppb, less than 5 percent of the permissible exposure limit and significantly less (p less than 0.01) than the mean TWA exposures occurring in the foam line and the finishing workers. Serial evaluation of the respiratory health of these six showed all persisted with respiratory symptoms, none had improvement in bronchial hyperresponsiveness to methacholine, and three had a greater than 15 percent decline in FEV1 on one of the days of spirometric testing over the five-year period from 1982 to 1986. Although we could not have predicted the outcome of asthma had these workers left the workplace and ceased isocyanate exposure entirely, occupational asthma persisted despite negligible ongoing TDI exposures.
通过特异性吸入激发试验表明，六名聚氨酯泡沫塑料工人患有甲苯二异氰酸酯（TDI）诱发的哮喘。所有人仍留在工作场所，从事TDI暴露极少的工作。哮喘组的平均暴露浓度和时间加权平均暴露浓度为0.64±0.46 ppb，低于允许暴露限值的5%，且显著低于（p<0.01）泡沫生产线和精加工工人的平均时间加权平均暴露量。对这六名工人的呼吸健康进行的连续评估显示，所有人都持续有呼吸道症状，没有人对乙酰甲胆碱的支气管高反应性有所改善，并且在1982年至1986年的五年期间，三名工人在肺活量测定测试的某一天FEV1下降超过15%。尽管如果这些工人离开工作场所并完全停止异氰酸酯暴露，我们无法预测哮喘的结果，但尽管TDI持续暴露可忽略不计，职业性哮喘仍持续存在。
