Moller D R, McKay R T, Bernstein I L, Brooks S M
Am Rev Respir Dis. 1986 Jul;134(1):175-6. doi: 10.1164/arrd.1986.134.1.175.
The natural history of isocyanate-induced asthma is not well documented. We evaluated a patient who developed persistent shortness of breath, wheezing, and cough after a massive exposure to toluene diisocyanate (TDI). Despite no further occupational exposures to isocyanates, he continued to have symptoms of asthma and variable airway obstruction 12 yr later. A methacholine inhalation challenge test was markedly positive, and a bronchial challenge test to TDI produced a dual asthmatic response. This report demonstrates that sensitivity to TDI can persist for many years in the absence of further occupational exposure and suggests that some patients with TDI-induced asthma do not recover from their disease after being removed from isocyanate exposure.
异氰酸酯诱发哮喘的自然病史尚无充分记录。我们评估了一名患者，该患者在大量接触甲苯二异氰酸酯（TDI）后出现持续性呼吸急促、喘息和咳嗽。尽管此后未再职业性接触异氰酸酯，但12年后他仍有哮喘症状和可变的气道阻塞。乙酰甲胆碱吸入激发试验呈明显阳性，TDI支气管激发试验产生双重哮喘反应。本报告表明，在无进一步职业接触的情况下，对TDI的敏感性可持续多年，提示一些TDI诱发哮喘的患者在脱离异氰酸酯接触后疾病并未康复。
