Department of POPs Lab, Shenzhen Center for Disease Control and Prevention, No. 21, 1st Road Tianbei, Luohu District, Shenzhen, Guangdong 518020, PR China.
Environ Int. 2012 Jul;42:47-52. doi: 10.1016/j.envint.2011.03.022. Epub 2011 Apr 30.
Sixty breast milk samples were collected in Shenzhen, China from July to November in 2007. The samples were analyzed of the concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs). The range of upper-bound for ∑TEQ-(PCDD/Fs+PCBs) in the samples was 4.10-35.3 pg TEQ g(-1) lipid (median: 10.6 pg TEQ g(-1) lipid; mean: 11.9 pg TEQ g(-1) lipid). The levels of the measured contaminants in the breast milk had significant correlations with the length of inhabitation period in Shenzhen (r=0.487, p<0.05 for PCDD/Fs, r=0.431, p<0.05 for PCBs and r=0.478, p<0.05 for ∑TEQ-(PCDD/Fs+PCBs)), and the consumption rate of fish (r=0.366, p<0.05 for PCDD/Fs, r=0.486, p<0.05 for PCBs and r=0.416, p<0.05 for ∑TEQ-(PCDD/Fs+PCBs)), respectively. Moreover, significant positive correlations were also detected between the participant's age (r=0.305, p<0.05 for ∑TEQ-PCBs and r=0.275, p<0.05 for ∑TEQ-(PCDD/Fs+PCBs)) and the body burdens of these contaminants respectively. It is estimated that the daily intake (EDI) of the sum of PCDD/Fs and DL-PCBs by the breast-fed infants was 5.60-161 pg TEQ kg(-1) bw per day (mean: 48.2 pg TEQ kg(-1) bw per day; median: 42.2 pg TEQ kg(-1) bw per day). The result showed that both the body burdens of PCDD/Fs and PCBs of the recruit population and the calculated EDI of the breast-fed infants were higher than those in the non-exposed areas in mainland China. This suggests that continuous surveillance on PCDD/Fs and PCBs levels in human milk is critical to more precisely evaluate the human health risk posed by the negative environmental impact in Shenzhen in the future.
2007 年 7 月至 11 月期间，在中国深圳采集了 60 份母乳样本。分析了这些样本中多氯二苯并对二恶英（PCDDs）、多氯二苯并呋喃（PCDFs）和多氯联苯（PCBs）的浓度。样品中∑TEQ-（PCDD/Fs+PCBs）的上限范围为 4.10-35.3 pg TEQ g(-1)脂质（中位数：10.6 pg TEQ g(-1)脂质；平均值：11.9 pg TEQ g(-1)脂质）。母乳中测量的污染物水平与在深圳的居住时间（PCDD/Fs：r=0.487，p<0.05；PCBs：r=0.431，p<0.05；∑TEQ-（PCDD/Fs+PCBs）：r=0.478，p<0.05）和鱼类的消费率（PCDD/Fs：r=0.366，p<0.05；PCBs：r=0.486，p<0.05；∑TEQ-（PCDD/Fs+PCBs）：r=0.416，p<0.05）呈显著正相关。此外，还检测到参与者年龄（PCBs：r=0.305，p<0.05；∑TEQ-（PCDD/Fs+PCBs）：r=0.275，p<0.05）与这些污染物的身体负荷之间存在显著正相关。据估计，母乳喂养婴儿每日摄入的 PCDD/Fs 和 DL-PCBs 总和（EDI）为 5.60-161 pg TEQ kg(-1) bw 每天（平均值：48.2 pg TEQ kg(-1) bw 每天；中位数：42.2 pg TEQ kg(-1) bw 每天）。结果表明，招募人群中 PCDD/Fs 和 PCBs 的身体负荷以及计算出的母乳喂养婴儿 EDI 均高于中国内地非暴露地区。这表明，对人类母乳中 PCDD/Fs 和 PCBs 水平进行持续监测，对于更准确地评估未来深圳环境负面影响对人类健康造成的风险至关重要。
