Ab Rahman Ahmad Kashfi, Abdullah Fatimah Haslina
Infectious Disease Clinic, Department of Medicine, Hospital Sultanah Nur Zahirah, Jalan Sultan Mahmud, 20400 Kuala Terengganu, Malaysia.
Microbiology Unit, Department of Pathology, Hospital Sultanah Nur Zahirah, Jalan Sultan Mahmud, 20400 Kuala Terengganu, Malaysia.
J Microbiol Immunol Infect. 2011 Feb;44(1):72-6. doi: 10.1016/j.jmii.2011.01.014. Epub 2011 Jan 13.
Malaria is endemic in Malaysia. Leishmaniasis is a protozoan infection rarely reported in Malaysia. Here, a 24-year-old Nepalese man who presented with prolonged fever and hepatosplenomegaly is reported. Blood film examination confirmed a Plasmodium vivax malaria infection. Despite being adequately treated for malaria, his fever persisted. Bone marrow examination showed presence of Leishman-Donovan complex. He was successfully treated with prolonged course of amphotericin B. The case highlights the importance of awareness among the treating physicians of this disease occurring in a foreign national from an endemic region when he presents with fever and hepatosplenomegaly. Coinfection with malaria can occur although it is rare. It can cause significant delay of the diagnosis of leishmaniasis.
疟疾在马来西亚呈地方性流行。利什曼病是一种在马来西亚很少报道的原生动物感染。在此,报告了一名24岁的尼泊尔男子,他出现长期发热和肝脾肿大。血片检查确诊为间日疟原虫疟疾感染。尽管对疟疾进行了充分治疗,但他的发热仍持续存在。骨髓检查显示存在利杜体。他通过长期使用两性霉素B成功治愈。该病例凸显了治疗医生认识到当来自地方病流行地区的外国国民出现发热和肝脾肿大时可能发生这种疾病的重要性。尽管罕见,但疟疾合并感染仍可能发生。它会导致利什曼病诊断的显著延迟。