Hospices Civils de Lyon, Department of Ophthalmology, Hôpital Edouard Herriot, Lyon, France.
Ophthalmology. 2011 Aug;118(8):1563-70. doi: 10.1016/j.ophtha.2011.01.001. Epub 2011 Apr 30.
To compare anterior chamber volume (ACV), iris volume, and iridolenticular contact (ILC) area before and after laser peripheral iridotomy (LPI) in eyes with pigment dispersion syndrome (PDS) using anterior segment optical coherence tomography (AS OCT) and image processing software.
Cross-sectional study.
Eighteen eyes of 18 patients with PDS; 30 eyes of 30 controls matched for age, gender, and refraction.
Anterior segment OCT imaging was performed in all eyes before LPI and 1, 4, and 12 weeks after LPI. At each visit, 12 cross-sectional images of the AS were taken: 4 in bright conditions with accommodation (accommodation), 4 in bright conditions without accommodation (physiological miosis), and 4 under dark conditions (physiologic mydriasis). Biometric parameters were estimated using AS OCT radial sections and customized image-processing software.
Anterior chamber volume, iris volume-to-length ratio, ILC area, AS OCT anterior chamber depth, and A-scan ultrasonography axial length.
Before LPI, PDS eyes had a significantly greater ACV and ILC area than control eyes (P<0.01) and a significantly smaller iris volume-to-length ratio than the controls (P<0.05). After LPI, ACV and ILC area decreased significantly in PDS eyes, but iris volume-to-length ratio increased significantly (P<0.02) and was not significantly different from that of controls. These biometric changes were stable over time. Iris volume-to-length ratio decreased significantly from accommodation to mydriasis and from miosis to mydriasis, both in PDS and control eyes (P<0.01). In PDS eyes, ILC area decreased significantly from accommodation to mydriasis, both before and after LPI (P<0.01). On multivariate analysis, greater anterior chamber (AC) volume (P<0.02) and larger AC depth (P<0.05) before LPI were significant predictors of a larger ILC area.
Pigment dispersion syndrome eyes do not have an iris that is abnormally large, relative to the AS size, but have a weakly resistant iris that is stretched and pushed against the lens when there is a pressure difference across the iris.
FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
使用眼前节光学相干断层扫描（AS-OCT）和图像处理软件比较色素播散综合征（PDS）患者激光周边虹膜切开术（LPI）前后前房容积（ACV）、虹膜容积和虹膜晶状体接触（ILC）面积。
横断面研究。
18 例 PDS 患者的 18 只眼；30 只年龄、性别和屈光度匹配的对照眼。
所有眼在 LPI 前和 LPI 后 1、4 和 12 周进行眼前节 OCT 成像。每次就诊时，采集 12 个眼前节的横截面图像：4 个在明条件下伴有调节（调节），4 个在明条件下无调节（生理性缩瞳），4 个在暗条件下（生理性散瞳）。使用 AS-OCT 径向切片和定制的图像处理软件估计生物测量参数。
前房容积、虹膜容积与长度比、ILC 面积、AS-OCT 前房深度和 A 型超声轴向长度。
在 LPI 之前，PDS 眼的 ACV 和 ILC 面积明显大于对照组（P<0.01），虹膜容积与长度比明显小于对照组（P<0.05）。LPI 后，PDS 眼的 ACV 和 ILC 面积明显下降，但虹膜容积与长度比明显升高（P<0.02），与对照组无差异。这些生物测量变化在时间上是稳定的。在 PDS 和对照组眼中，虹膜容积与长度比从调节到散瞳、从缩瞳到散瞳均显著降低（P<0.01）。在 PDS 眼中，ILC 面积在 LPI 前后从调节到散瞳均显著降低（P<0.01）。多变量分析显示，LPI 前较大的前房（AC）容积（P<0.02）和较大的 AC 深度（P<0.05）是 ILC 面积较大的显著预测因素。
色素播散综合征眼的虹膜相对于眼前节大小并不异常增大，而是在虹膜两侧存在压力差时，虹膜较软，被拉伸并推向晶状体。
作者没有与本文讨论的任何材料有关的专有或商业利益。
