Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging & Department of Psychiatry, Nijmegen, The Netherlands.
Curr Opin Neurobiol. 2011 Jun;21(3):402-7. doi: 10.1016/j.conb.2011.04.002. Epub 2011 Apr 29.
Dopamine has long been implicated in a wide variety of high-level cognitive processes, ranging from working memory to rule learning and attention switching. Notable progress has been made in the past decades, but the mechanisms underlying effects of dopamine on high-level cognition remain unclear. This article reviews evidence for an important role of the striatum and its interaction with the prefrontal cortex and suggests a variety of ways by which changes in dopamine transmission can bias high-level cognition.
多巴胺长期以来一直与各种高级认知过程有关，从工作记忆到规则学习和注意力转换。在过去的几十年中取得了显著的进展，但多巴胺对高级认知的影响的机制仍不清楚。本文综述了纹状体及其与前额叶皮层相互作用的重要作用的证据，并提出了多巴胺传递变化可以影响高级认知的多种方式。
