Department of Rheumatology, Lund University, Skåne University Hospital, Malmö, Sweden.
Rheumatology (Oxford). 2011 Sep;50(9):1612-7. doi: 10.1093/rheumatology/ker077. Epub 2011 Apr 29.
To study pregnancy and fetal outcome in women with primary SS (pSS) compared with women in the general population.
In a nested case-control setting, variables related to pregnancy and fetal outcomes were compared. Cases (n = 16) were identified through registry linkage (Malmö pSS registry and a database entailing information of all pregnancies and deliveries in Malmö from 1990 through 2006). For each pregnancy with pSS, the following five deliveries from the same registry were chosen as controls (n = 80).
All cases fulfilled the American European Consensus Criteria for pSS and were positive for ANA and anti-SSA antibodies. Date of diagnosis was before pregnancy in 10 women and after delivery in 6. Mean age at delivery was significantly higher in women with pSS (33.6 years) vs controls (29.8 years). While pregnancy duration did not differ, mean birthweight was significantly lower in offspring of pSS mothers (3010 g) vs babies of control mothers (3458 g). Normal partus in contrast to vacuum extraction or Caesarean section was significantly more frequent in healthy women than in pSS women (83 vs 56%). Other pregnancy outcomes such as parity, miscarriages and Apgar score did not differ. There were no significant differences between women with a pSS diagnosis before or after the index pregnancy. Only one of the included pregnancies was complicated by intrauterine AV block.
Pregnancy occurs later in life in pSS women. Mothers with pSS give birth to offspring with lower birthweight and less commonly have normal partus.
研究原发性干燥综合征（pSS）女性的妊娠和胎儿结局与普通人群相比有何不同。
在巢式病例对照研究中，比较了与妊娠和胎儿结局相关的变量。病例（n=16）通过登记处关联（马尔默 pSS 登记处和一个包含 1990 年至 2006 年马尔默所有妊娠和分娩信息的数据库）确定。对于每例患有 pSS 的妊娠，从同一登记处选择以下 5 例分娩作为对照（n=80）。
所有病例均符合美国欧洲共识标准 pSS，ANA 和抗 SSA 抗体均为阳性。10 例患者的诊断日期在妊娠前，6 例在分娩后。pSS 女性的分娩年龄明显高于对照组（33.6 岁）（29.8 岁）。虽然妊娠持续时间没有差异，但 pSS 母亲的新生儿出生体重明显较低（3010g）与对照组母亲的婴儿（3458g）。正常分娩与真空提取或剖宫产相比，健康女性明显更为常见（83% vs 56%）。其他妊娠结局如产次、流产和阿普加评分无差异。在指数妊娠前后诊断为 pSS 的女性之间没有显著差异。只有 1 例包含的妊娠并发宫内房室传导阻滞。
pSS 女性妊娠发生在生命后期。患有 pSS 的母亲所生子女出生体重较低，正常分娩较少。
