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患有干燥综合征和肺栓塞的孕妇剖宫产围手术期管理:一例病例报告

Perioperative management of caesarean section for a pregnant woman with Sjögren's disease and pulmonary embolism: a case report.

作者信息

Liu Fanghao, Wang Xiaohui, Yuan Shu, Xu Lin, Shan Kaiyue, Wang Longfei, Huang Jianting, Zheng Qiang

机构信息

Department of Anesthesiology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, China.

出版信息

Front Cardiovasc Med. 2025 Apr 11;12:1467309. doi: 10.3389/fcvm.2025.1467309. eCollection 2025.

Abstract

BACKGROUND

Sjögren's disease (SjD) is a chronic inflammatory autoimmune disease with significant female predominance, characterised by lymphocyte proliferation and progressive damage to exocrine glands. The complexity of the condition of women with SjD and the incidence of complications substantially increase during pregnancy, which undoubtedly has consequences on both maternal health and neonatal outcomes. Pulmonary embolism (PE) is associated with increased perinatal mortality. However, PE has rarely been reported in pregnant women with SjD.

CASE PRESENTATION

A 40-year-old pregnant woman was diagnosed as having SjD. During admission, she experienced chest tightness and suffocation and was scheduled for caesarean section under combined spinal-epidural anaesthesia because of sustained low oxygen saturation and foetal distress. Postoperative pulmonary artery computed tomography angiography confirmed that the patient had developed a pulmonary embolism during the perioperative period. After multidisciplinary consultation, the patient underwent inferior vena cava filter implantation, anticoagulation, oxygen therapy, and anti-infection therapy; both the mother and neonate recovered and were discharged.

CONCLUSION

Early identification and comprehensive perioperative monitoring during the prenatal period are vital in patients with SjD complicated by PE.

摘要

背景

干燥综合征(SjD)是一种慢性炎症性自身免疫性疾病,女性患者占比显著,其特征为淋巴细胞增殖以及外分泌腺的进行性损伤。患有SjD的女性在孕期病情的复杂性及并发症发生率会大幅增加,这无疑会对孕产妇健康和新生儿结局产生影响。肺栓塞(PE)与围产期死亡率增加相关。然而,SjD孕妇中PE的报道很少。

病例报告

一名40岁孕妇被诊断为患有SjD。入院期间,她出现胸闷和窒息症状,由于持续低氧饱和度和胎儿窘迫,计划在腰麻-硬膜外联合麻醉下进行剖宫产。术后肺动脉计算机断层扫描血管造影证实患者在围手术期发生了肺栓塞。经过多学科会诊,患者接受了下腔静脉滤器植入、抗凝、氧疗和抗感染治疗;母婴均康复出院。

结论

对于合并PE的SjD患者,孕期早期识别和全面的围手术期监测至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbe0/12021838/8fcf36bfe025/fcvm-12-1467309-g001.jpg

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