Jurna Martin, Herek Jennifer L, Offerhaus Herman L
Optical Sciences group, MESA+ Institute for Nanotechnology, Faculty of Science and Technology (TNW), University of Twente, The Netherlands.
Appl Opt. 2011 May 1;50(13):1839-42. doi: 10.1364/AO.50.001839.
Detection of molecules using vibrational resonances in the fingerprint region for narrowband coherent anti-Stokes Raman scattering (CARS) is challenging. The spectrum is highly congested resulting in a large background and a reduced specificity. Recently we introduced vibrational phase contrast CARS (VPC-CARS) microscopy as a technique capable of detecting both the amplitude and phase of the CARS signal, providing background-free images and high specificity. In this paper we present a new implementation of VPC-CARS based on a third-order cascaded phase-preserving chain, where the CARS signal is generated at a single (constant) wavelength independent of the vibrational frequency that is addressed. This implementation will simplify the detection side considerably.
利用窄带相干反斯托克斯拉曼散射（CARS）指纹区的振动共振来检测分子具有挑战性。该光谱高度拥挤，导致背景大且特异性降低。最近，我们引入了振动相衬CARS（VPC-CARS）显微镜技术，该技术能够检测CARS信号的幅度和相位，提供无背景图像和高特异性。在本文中，我们提出了一种基于三阶级联保相链的VPC-CARS新实现方式，其中CARS信号在与所探测的振动频率无关的单一（恒定）波长处产生。这种实现方式将大大简化检测端。
