Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
J Korean Med Sci. 2011 May;26(5):599-603. doi: 10.3346/jkms.2011.26.5.599. Epub 2011 Apr 21.
Heart transplantation is now regarded as the treatment of choice for end-stage heart failure. To improve long-term results of the heart transplantation, we analyzed causes of death relative to time after transplantation. A total of 201 consecutive patients, 154 (76.6%) males, aged ≥ 17 yr underwent heart transplantation between November 1992 and December 2008. Mean ages of recipients and donors were 42.8 ± 12.4 and 29.8 ± 9.6 yr, respectively. The bicaval anastomosis technique was used since 1999. Mean follow up duration was 6.5 ± 4.4 yr. Two patients (1%) died in-hospital due to sepsis caused by infection. Late death occurred in 39 patients (19.4%) with the most common cause being sepsis due to infection. The 1-, 5-, and 10-yr survival rates in these patients were 95.5% ± 1.5%, 86.9% ± 2.6%, and 73.5% ± 4.1%, respectively. The surgical results of heart transplantation in adults were excellent, with late mortality due primarily to infection, malignancy, and rejection. Cardiac deaths related to cardiac allograft vasculopathy were very rare.
心脏移植现在被认为是治疗终末期心力衰竭的首选方法。为了改善心脏移植的长期效果，我们分析了与移植后时间相关的死亡原因。1992 年 11 月至 2008 年 12 月，共有 201 例连续患者（154 例男性，年龄≥17 岁）接受了心脏移植。受体和供体的平均年龄分别为 42.8±12.4 岁和 29.8±9.6 岁。自 1999 年以来，我们一直采用双腔静脉吻合技术。平均随访时间为 6.5±4.4 年。两名患者（1%）因感染引起的败血症住院死亡。39 例患者（19.4%）发生晚期死亡，最常见的死亡原因是感染引起的败血症。这些患者的 1、5 和 10 年生存率分别为 95.5%±1.5%、86.9%±2.6%和 73.5%±4.1%。成人心脏移植的手术结果非常出色，晚期死亡率主要归因于感染、恶性肿瘤和排斥反应。与心脏同种异体血管病相关的心脏死亡非常罕见。
